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Prognostic value of microRNAs in hepatocellular carcinoma: a meta-analysis
Overall survival of HCC patients with high expression of tissue miR-9,miR-22,MiR-155, mi-199a, MiR-200a, miG-203, miB-221 and blood MiRNAs, including blood mi R-21, miR -148a,mi-192, miC-224 demonstrate significantly prognostic value, which is a potential prognostic candidates for predicting OS in HCC.
Study on the Antihypertensive Mechanism of Astragalus membranaceus and Salvia miltiorrhiza Based on Intestinal Flora-Host Metabolism
The research indicated that HD had a good antihypertensive effect, which may be driven by the protective intestinal flora and beneficial metabolites induced by it, and the metabolites were closely related to the changes of intestinal flora.
Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats
It is shown that RTA treatment rescues the ox-LDL-induced autophagy impairment in HUVECs and improves endothelium-dependent vasodilation function in SHR and activates the AMP-activated protein kinase (AMPK) signaling pathway.
Quercetin Attenuates Atherosclerosis via Modulating Oxidized LDL-Induced Endothelial Cellular Senescence
GO and KEGG analysis indicated nitrogen metabolism, ECM-receptor interaction, complement, and coagulation cascades, p53 and mTOR signaling pathway were involved in the pharmacological mechanisms of quercetin against ox-LDL.
Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation
Chemical sympathectomy with administration of 6-OHDA caused dysregulation of the cardiac autonomic nervous system and myocardial injuries and Mecobalamin alleviated inflammatory and my heart rate variability and ECG and echocardiography results.
Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs
PPII treatment may suppress bladder cancer cell migration and invasion by regulating the expression of EMT-associated genes and MMPs, suggesting that PPII may serve as a potential therapeutic option for inhibiting bladder cancer metastasis.
Long non-coding RNA and mRNA analysis of Ang II-induced neuronal dysfunction
This is the first report of the lncRNA–mRNA integrated profile of SH-SY5Y cells induced by Ang II, and the metabolism of the vitamin B group, the synthesis of unsaturated fatty acids and glycosphingolipids are involved in the Ang II-related cognitive impairment.
Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway
Tan II A exerted a strong protective effect on HUVECs, and the mechanism was caused, at least in part, by a blockade in the Rho/ROCK pathway, presumably through the down-regulation of ITG A5.
Prognostic value of microRNAs in gastric cancer: a meta-analysis
Background Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis
β-Sitosterol regulated microRNAs in endothelial cells against an oxidized low-density lipoprotein.
The present study found that miRNAs might be the targets of β-sitosterol and play vital roles in transcriptional regulation in endothelial protective and antiatherogenic effects against ox-LDL, and explored DE microRNA (miRNA).