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Sterilizing immunity to influenza virus infection requires local antigen-specific T cell response in the lungs
Sterilizing immunity is a unique immune status, which prevents effective virus infection into the host. It is different from the immunity that allows infection but with subsequent successfulExpand
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Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.
BACKGROUND Millions of people are infected by the influenza virus worldwide every year. Current selections of anti-influenza agents are limited and their effectiveness and drug resistance are stillExpand
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IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection.
Th1 cells control their activity by producing regulatory IL-10. Here we report that Th1 cell-derived IL-10 facilitates their expansion and, in addition, augments Th1 cell production of IFN-γ, TNF-αExpand
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Altered T-bet Dominance in IFN-γ–Decoupled CD4+ T Cells with Attenuated Cytokine Storm and Preserved Memory in Influenza
Cytokine storm has been postulated as one of the major causes of mortality in patients with severe respiratory viral infections such as influenza. With the help of an influenza Ag- specific mouseExpand
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Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model
Influenza virus infection often causes severe disease and acute respiratory distress syndrome. It is a common belief that overwhelming immune response contributes to the severe illness. PhysiciansExpand
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LAG-3 expressing antigen-specific CD4+ T cells attenuate lung inflammation during acute influenza virus infection
The host immune system responds to influenza virus infection for eradication of the virus but the immune response associated inflammation causes tissue injury and damage to the host as well. In ourExpand
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Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system
The host immune system responds to influenza virus infection for eradication of the virus but the immune response associated inflammation causes tissue injury and damage to the host as well. SevereExpand
Viral neuraminidase and the biphasic immune regulation by host cytokine interleukin-10 in influenza (VIR2P.1030)
Influenza virus invades the host while the host immune response defends to clear the virus. These responses may result in excessive inflammation with tissue injury, which is as detrimental as theExpand