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p27Kip1 controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks). Here we show that Cdk inhibition and p27 stability are regulated through direct phosphorylation by tyrosine kinases. A conserved tyrosine residue (Y88) in the Cdk-binding domain of p27 can be phosphorylated by the Src-family kinase Lyn and the(More)
ProtoRINA is a user-space prototype of the Recursive InterNetwork Architecture. RINA is a new architecture that builds on the fundamental principle that "networking is inter-process communication". As a consequence, RINA overcomes inherent weaknesses of the current Internet, e.g., security, mobility support, and manageability. ProtoRINA serves not only as a(More)
Traditionally, well-defined three-dimensional structure has been thought to be essential for protein function. However, myriad biological functions are performed by highly dynamic, intrinsically disordered proteins (IDPs). IDPs often fold upon binding their biological targets and frequently show 'binding diversity' by targeting multiple ligands. We sought(More)
Our reply supplies supplementary clinical and laboratory fi ndings that could be useful for discussion. During our patient's hospitalization , we were able to investigate 6/8 diagnostic criteria for HLH proposed by the Histiocyte Society (3). Of these, only 2 or 3 were found: persistent fever at 38.5°C; hypertriglyceridemia at 267 mg/dL (analysis performed(More)
Management is a vital component for delivering requested network services. The inability of the current Internet architecture to accommodate modern requirements has spurred attempts to provide novel network management solutions. Existing approaches often restrict the range of policies that can be employed to adapt to diverse network conditions. They are(More)
Collagen triple helix repeat-containing 1 (CTHRC1), a novel oncogene, was identified to be aberrantly overexpressed in several malignant tumors. However, the expression profile of CTHRC1 and its clinical significance in non-small cell lung cancer (NSCLC) remain unknown. In this study, we showed that CTHRC1 was evidently overexpressed in human NSCLC tissues(More)