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BACKGROUND Serum uric acid (UA), a natural scavenger of peroxynitrite, has been found to be of lower levels in patients with multiple sclerosis (MS) in some recent preliminary studies. OBJECTIVE To evaluate the correlation between serum UA levels and several clinical parameters of MS reliably. METHODS We surveyed studies on the serum UA levels and MS(More)
BACKGROUND Over exposure to manganese (Mn) can damage the human central nervous system and potentially cause liver toxicity. Alcohol drinking is also one of the well-known harmful factors to hepatic organism. The interaction between Mn exposure and alcohol consumption to liver function was investigated in this study. METHODS A total of 1112 on-the-spot(More)
PURPOSE The aims of this study were to investigate the effects of manganese (Mn) dust exposure on lung functions and evaluate the potential synergistic effect between smoking and Mn dust exposure among refinery workers. METHODS A retrospective study including 1658 workers in a ferromanganese refinery was conducted, with subjects who were from the Guangxi(More)
OBJECTIVE To determine the relationship between biomarkers of exposure, disease and susceptibility, and early health effects and long-term diseases related to occupational manganese (Mn) exposure. DESIGN Baseline survey of a longitudinal cohort study of workers in a ferromanganese refinery. PARTICIPANTS A total of 1888 individuals (1197 men, 691 women;(More)
Chronic manganese exposure can produce cognitive deficits; however, the underlying mechanism remains unclear; reliable peripheral biomarker of Mn neurotoxicity have not yet been fully developed. Hence, this study aimed to investigate the mechanism of Mn-induced cognitive deficits and the potential biomarker of Mn neurotoxicity in rats. Thirty-two male(More)
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