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  • Seong Heon Kim, Gopinadhan N. Anilkumar, +17 authors Neng-Yang Shih
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2011 (First Publication: 1 December 2011)
  • The SAR of a novel pyrazinyl-piperazinyl-piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and reduction of hERG inhibition is described.Expand
  • Anilkumar G. Nair, Michael K. C. Wong, +14 authors Joseph A. Kozlowski
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2014 (First Publication: 15 February 2014)
  • The structure-human CXCR3 binding affinity relationship of a series of pyridyl/pyrazinyl-piperazinyl-piperidine derivatives were explored with a focus to improve PK, hERG and metabolic profiles.Expand
  • E J Iorio, Yuefei Shao, Chun Te Chen, Hildebert Wagner, W. Clark Still
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2001 (First Publication: 1 July 2001)
  • Synthetic chemosensors hold great potential in many diagnostic applications. In this study, we describe the design and preparation of the first encoded combinatorial library of chemosensors forExpand