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C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction
- Haijian Sun, Xuexue Zhu, Yue-tao Zhou, Weiwei Cai, Liying Qiu
- Biology, ChemistryInternational journal of molecular sciences
- 26 May 2017
It is observed that treatment with ox-LDL inhibited the proliferation, migration, angiogenesis and the generation of NO, while stimulated the apoptosis and reactive oxygen species (ROS) production in HUVECs, providing the first evidence that CTRP9 attenuated ox- LDL-induced endothelial injury by antioxidant enzyme inductions dependent on PGC-1α/AMPK activation.
Vaccarin prevents ox-LDL-induced HUVEC EndMT, inflammation and apoptosis by suppressing ROS/p38 MAPK signaling.
- Leilei Gong, Yueyue Lei, Liying Qiu
- Biology, ChemistryAmerican journal of translational research
- 15 April 2019
It is suggested that vaccarin impeded ox-LDL-triggered HUVEC inflammation, EndMT and apoptosis via inhibition of ROS/p38 MAPK signaling pathway and may have a therapeutic effect on endothelial injury-related disorders.
Salusin-β mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.
Interactions of TLR4 and PPARγ, Dependent on AMPK Signalling Pathway Contribute to Anti-Inflammatory Effects of Vaccariae Hypaphorine in Endothelial Cells
- Haijian Sun, Xuexue Zhu, Wei Lin, Yue-tao Zhou, Weiwei Cai, Liying Qiu
- Biology, MedicineCellular Physiology and Biochemistry
- 3 July 2017
The results suggested that VH ameliorated LPS-induced inflammatory cytokines production in endothelial cells via inhibition of TLR4 and activation of PPARγ, dependent on AMPK signalling pathway.
Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development
ASM is a negative regulator of natural and iTreg, and induction of ASM deficient T cells in the presence of TGF-β and IL-2 lead to a significantly higher number of Foxp3+ induced Treg (iTreg) compared with control T-cells.
Cell cycle arrest and cell apoptosis induced by Equisetum hyemale extract in murine leukemia L1210 cells.
Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells
An unexpected differential role of DJ-1 is revealed in the development of nTregs and iTregs, which is less sensitive to pSmad2 and pStat5 signalling but had activated AKT/mTOR signalling.
The ethyl acetate fraction of Polytrichum commune L.ex Hedw induced cell apoptosis via reactive oxygen species in L1210 cells.
DJ‐1/Park7 Sensitive Na+/H+ Exchanger 1 (NHE1) in CD4+ T Cells
DJ‐1 is a powerful regulator of ROS production as well as NHE1 expression and activity in CD4+ T cells, pointing to a role of ROS in the up‐regulation of N HE1 in DJ‐1−/− CD4- T cells.
Correlations between quantitative parameters of contrast-enhanced ultrasound and vasculogenic mimicry in murine tumor model: a novel noninvasive technique for assessment?
Three quantitative parameters related to VM were obtained and the relationships between CEUS and VM were established, suggesting CEUS might provide a novel noninvasive method to assess VM in vivo.