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LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.
The results indicate that the HOTTIP/WDR5/HOXA9/Wnt axis contributes to PCSC stemness and is a potential therapeutic target for PDAC. Expand
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade
It is demonstrated that OPN facilitates chemotactic migration, and alternative activation of macrophage markers, and promotes the PD-L1 expression in HCC via activation of the CSF1-CSF1R pathway in macrophages. Expand
Downregulation of HDPR1 is associated with poor prognosis and affects expression levels of p120‐catenin and β‐catenin in nonsmall cell lung cancer
The function of HDPR1 on regulating p120ctn may play an important role in human lung carcinogenesis and Restoration ofHDPR1 gene may be a new therapeutic target of lung cancer. Expand
Targeting cancer stem cells and their niche: perspectives for future therapeutic targets and strategies.
It is hoped that new strategies and related therapeutic approaches as outlined here may help prevent the formation of the metastatic niche, as well as counter tumor progression and metastatic growth. Expand
miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 Expression
  • Yan Wang, Yue Zhao, +13 authors C. Bruns
  • Medicine
  • Annals of surgery
  • 1 November 2016
Knockdown of miR-221 in 5-FU resistant cells resulted in reduced cell proliferation, increased apoptosis, restored chemosensitivity, and led to inactivation of the Wnt/&bgr;-catenin pathway mediated by alteration in DKK2 expression. Expand
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
It is demonstrated that a long noncoding RNA LNMAT1 promotes LN metastasis of bladder cancer via recruitment of TAMs through epigenetic regulation of CCL2 expression, which provides a plausible mechanism for L NMAT1-modulated tumor microenvironment in lymphatic metastasis. Expand
Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K/AKT/NF-κB signaling in the granulosa cells of PCOS patients.
The up-regulated expression of WNT5a in PCOS increases inflammation and oxidative stress predominantly via the phosphatidylinositol 3-kinase/AKT/NF-κB signaling pathway, indicating a novel regulatory system for chronic inflammation in PCos. Expand
Protective Effect of Resveratrol against IL-1β-Induced Inflammatory Response on Human Osteoarthritic Chondrocytes Partly via the TLR4/MyD88/NF-κB Signaling Pathway: An “in Vitro Study”
It is suggested that resveratrol prevented IL-1β-induced inflammation in human articular chondrocytes at least in part by inhibiting the TLR4/MyD88/NF-κB signaling pathway suggesting that res veratrol has the potential to be used as a nutritional supplement to counteract OA symptoms. Expand
The long non-coding RNA FOXD2-AS1 promotes bladder cancer progression and recurrence through a positive feedback loop with Akt and E2F1
A novel regulatory pattern involving FOXD2-AS1, Akt, and E2F1, which may be a novel target for the treatment of bladder cancer and has the potential to be a new recurrence predictor is demonstrated. Expand
Connexin 43 recruits E-cadherin expression and inhibits the malignant behaviour of lung cancer cells.
Connexin 43 may induce E-cadherin expression and inhibit cell proliferation and progression of lung cancer in human non-small cell lung cancers (NSCLC). Expand