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Shift-reduce dependency parsers give comparable accuracies to their chart-based counterparts, yet the best shift-reduce constituent parsers still lag behind the state-of-the-art. One important reason is the existence of unary nodes in phrase structure trees, which leads to different numbers of shift-reduce actions between different outputs for the same(More)
The stability of the Wnt pathway transcription factor beta-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers, making this pathway an attractive target for anticancer therapies. However, the development of targeted Wnt pathway inhibitors has been hampered by the limited(More)
The transition of cells from an epithelial to a mesenchymal phenotype is a critical event during morphogenesis in multicellular organisms and underlies the pathology of many diseases, including the invasive phenotype associated with metastatic carcinomas. Transforming growth factor beta (TGFbeta) is a key regulator of epithelial-to-mesenchymal transition(More)
The Rho family of small guanosine triphosphatases regulates actin cytoskeleton dynamics that underlie cellular functions such as cell shape changes, migration, and polarity. We found that Smurf1, a HECT domain E3 ubiquitin ligase, regulated cell polarity and protrusive activity and was required to maintain the transformed morphology and motility of a tumor(More)
It has been shown that news events influence the trends of stock price movements. However, previous work on news-driven stock market prediction rely on shallow features (such as bags-of-words, named entities and noun phrases), which do not capture structured entity-relation information , and hence cannot represent complete and exact events. Recent advances(More)
R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth factors. Despite the biological and therapeutic significance, the molecular mechanism of R-spondin action remains unclear. Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are(More)