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The stability of the Wnt pathway transcription factor beta-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity has been implicated in many cancers, making this pathway an attractive target for anticancer therapies. However, the development of targeted Wnt pathway inhibitors has been hampered by the limited(More)
Shift-reduce dependency parsers give comparable accuracies to their chart-based counterparts, yet the best shift-reduce constituent parsers still lag behind the state-of-the-art. One important reason is the existence of unary nodes in phrase structure trees, which leads to different numbers of shift-reduce actions between different outputs for the same(More)
Several mechanisms have been proposed to account for the origination of new genes. Despite extensive case studies, the general principles governing this fundamental process are still unclear at the whole-genome level. Here, we unveil genome-wide patterns for the mutational mechanisms leading to new genes and their subsequent lineage-specific evolution at(More)
Mechanical loads are required for optimal bone mass. One mechanism whereby mechanical loads are transduced into localized cellular signals is strain-induced fluid flow through lacunae and canaliculi of bone. Gap junctions (GJs) between osteocytes and osteoblasts provides a mechanism whereby flow-induced signals are detected by osteocytes and transduced to(More)
It has been shown that news events influence the trends of stock price movements. However, previous work on news-driven stock market prediction rely on shallow features (such as bags-of-words, named entities and noun phrases), which do not capture structured entity-relation information , and hence cannot represent complete and exact events. Recent advances(More)
L1 elements are the only active autonomous retrotransposons in the human genome. The nonautonomous Alu elements, as well as processed pseudogenes, are retrotransposed by the L1 retrotransposition proteins working in trans. Here, we describe another repetitive sequence in the human genome, the SVA element. Our analysis reveals that SVA elements are currently(More)