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The Genia event task, a bio-molecular event extraction task, is arranged as one of the main tasks of BioNLP Shared Task 2011. As its second time to be arranged for community-wide focused efforts, it aimed to measure the advance of the community since 2009, and to evaluate generalization of the technology to full text papers. After a 3-month system(More)
A significant fraction of infants born to mothers taking selective serotonin reuptake inhibitors (SSRIs) during late pregnancy display clear signs of antidepressant withdrawal indicating that these drugs can penetrate fetal brain in utero at biologically significant levels. Previous studies in rodents have demonstrated that early exposure to some(More)
The Genia Event Extraction task is organized for the third time, in BioNLP Shared Task 2013. Toward knowledge based construction , the task is modified in a number of points. As the final results, it received 12 submissions, among which 2 were withdrawn from the final report. This paper presents the task setting, data sets, and the final results with(More)
During development of the nervous system, the fate of stem cells is regulated by a cell surface receptor called Notch. Notch is also present in the adult mammalian brain; however, because Notch null mice die during embryonic development, it has proven difficult to determine the functions of Notch. Here, we used Notch antisense transgenic mice that develop(More)
Functional magnetic resonance imaging was employed before and after six native English speakers completed lexical tone training as part of a program to learn Mandarin as a second language. Language-related areas including Broca's area, Wernicke's area, auditory cortex, and supplementary motor regions were active in all subjects before and after training and(More)
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is characterized by a cholinergic deficit. Potent, reversible, and brain-targeted BChE inhibitors (cymserine analogs) were developed based on binding domain structures to help(More)
Wireless sensor networks are tightly associated with the underlying environment in which the sensors are deployed. The global topology of the network is of great importance to both sensor network applications and the implementation of networking functionalities. In this paper we study the problem of topology discovery, in particular, identifying boundaries(More)
Myeloid-derived suppressor cells (MDSCs) represent heterogeneous immunosuppressive cells in multiple cancer types and display potent immunosuppressive activity on T cells. We have shown the increased expression of IDO in breast cancer. Because IDO plays a pivotal role in immune tolerance via suppressing T cell function, the aim of this study was to(More)
Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically give rise to multiclonal or monoclonal prostate cancer metastases is largely unknown, although studies at single chromosomal loci are consistent with the(More)