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Upland cotton is a model for polyploid crop domestication and transgenic improvement. Here we sequenced the allotetraploid Gossypium hirsutum L. acc. TM-1 genome by integrating whole-genome shotgun reads, bacterial artificial chromosome (BAC)-end sequences and genotype-by-sequencing genetic maps. We assembled and annotated 32,032 A-subgenome genes and(More)
We propose a wavelength-division-multiplexed (WDM) passive optical network (PON) to provide conventional unicast data and downstream multicast function. At the optical line terminal (OLT), for each WDM channel, a dual-drive Mach-Zehnder modulator (DDMZM) is used to generate a sub-carrier double-sideband differential-phase-shift-keying (DPSK) signal. All the(More)
With increasing complexity of 3D geometric models and growing demand for advanced modeling functionality, significant effort is being devoted to the design of efficient, reliable, and scalable algorithms for digital geometry processing. We introduce a multi-scale surface representation that enables sophisticated editing functionality at different(More)
Anesthetics have been reported to promote Alzheimer’s disease neuropathogenesis by inducing amyloid beta (Aβ) protein accumulation and apoptosis. The aim of this study was to evaluate the effect of propofol on the apoptosis, Aβ accumulation, and inflammation induced by sevoflurane in human neuroglioma cells. Human neuroglioma cells were treated with or(More)
Hypoxic pulmonary hypertension is a pathophysiological process important in the development of various cardiopulmonary diseases. Recently, we found that sulfur dioxide could be produced endogenously by pulmonary vessels, and that it showed vascular regulatory capabilities. In this paper, we examined the role of sulfur dioxide in hypoxic pulmonary vascular(More)
There has been a recent explosion of interest in spiking neural networks (SNNs), which code information as spikes or events in time. Spike encoding is widely accepted as the information medium underlying the brain, but it has also inspired a new generation of neuromorphic hardware. Although electronics can match biological time scales and exceed them, they(More)
We demonstrate for the first time an excitable laser using graphene. This technology is a potential candidate for applications in novel all-optical devices for information processing and computing. Spike processing has evolved in biological (nervous systems) and engineered (neuromorphic analog VLSI) systems where information is encoded as events in time.(More)
Pancreatic cancer has a poor prognosis, even with surgery. ING4 is a member of the inhibitor of growth (ING) tumor suppressor family that has potent inhibitory effects on a variety of tumors; meanwhile, radiotherapy is a common adjunctive therapy for pancreatic cancer. Prior to this study, the effectiveness of a combination of ING4 gene-therapy and(More)