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Cypermethrin (CYP), a widely used Type II pyrethroid pesticide, is one of the most common contaminants in the freshwater aquatic system. We studied the effects of CYP exposure on the induction of hepatic oxidative stress, DNA damage and the alteration of gene expression related to apoptosis in adult zebrafish. Hepatic mRNA levels for the genes encoding(More)
Transcriptional engineering has received significant attention for improving strains by modulating the behavior of transcription factors, which could be used to reprogram a series of gene transcriptions and enable multiple simultaneous modifications at the genomic level. In this study, engineering of the cAMP receptor protein (CRP) was explored with the aim(More)
for their help during my stay here at Pittsburgh. Finally, I would like to thank the Department of Mathematical Sciences at Carnegie Mellon University for creating a comfortable environment of study. In particular, I want to thank Professor William J. Hrusa for being such an understanding and generous graduate advisor. Special thanks go to my family for(More)
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