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The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2 which we(More)
Human embryonic stem (hES) cells can differentiate in vitro, forming embryoid bodies (EBs) composed of derivatives of all three embryonic germ layers. Spontaneously contracting outgrowths from these EBs contain cardiomyocytes (CMs); however, the types of human CMs and their functional properties are unknown. This study characterizes the contractions and(More)
The Web Ontology Language OWL is currently the most prominent formalism for representing ontologies in Semantic Web applications. OWL is based on description logics, and automated reasoners are used to infer knowledge implicitly present in OWL ontologies. However, because typical description logics obey the classical principle of explosion, reasoning over(More)
OBJECTIVES The objectives of this study were to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in livestock and related workers in four Chinese provinces and the characteristics of these isolates. METHODS Nasal swabs were collected from animals and farm workers in four Chinese provinces. MRSA isolates were(More)
The recent discovery of a variety of receptors has led to new models for hormone perception in plants. In the case of the hormone abscisic acid (ABA), which regulates plant responses to abiotic stress, perception seems to occur both at the plasma membrane and in the cytosol. The cytosolic receptors for ABA have recently been identified as complexes between(More)
A four-valued description logic has been proposed to reason with description logic based inconsistent knowledge bases. This approach has a distinct advantage that it can be implemented by invoking classical reasoners to keep the same complexity as under the classical semantics. However, this approach has so far only been studied for the basid description(More)
Four-valued description logic has been proposed to reason with description logic based inconsistent knowledge bases, mainly ALC. This approach has a distinct advantage that it can be implemented by invoking classical reasoners to keep the same complexity as classical semantics. In this paper, we further study how to extend the four-valued semantics to more(More)
In this study we investigate the gene regulatory functions of Drosophila Fish-hook (Fish), a high mobility group (HMG) Sox protein that is essential for embryonic segmentation. We show that the Fish HMG domain binds to the vertebrate Sox protein consensus DNA binding sites, AACAAT and AACAAAG, and that this binding induces an 85 degrees DNA bend. In(More)