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Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-related protein, Caspr/Paranodin (NCP1).(More)
In vector space model (VSM), text representation is the task of transforming the content of a textual document into a vector in the term space so that the document could be recognized and classified by a computer or a classifier. Different terms (i.e. words, phrases, or any other indexing units used to identify the contents of a text) have different(More)
In this paper, we define and study a new opinionated text data analysis problem called Latent Aspect Rating Analysis (LARA), which aims at analyzing opinions expressed about an entity in an online review at the level of topical aspects to discover each individual reviewer's latent opinion on each aspect as well as the relative emphasis on different aspects(More)
Polarization of epithelial cells depends on a hierarchical process whereby specific membrane-associated proteins become targeted to specialized membrane domains. Here, we describe a novel Drosophila protein, Discs Lost (DLT), that plays a crucial role in the polarization of embryonic epithelia during cellular blastoderm formation. At subsequent stages of(More)
Mining detailed opinions buried in the vast amount of review text data is an important, yet quite challenging task with widespread applications in multiple domains. <i>Latent Aspect Rating Analysis</i> (LARA) refers to the task of inferring both opinion ratings on topical aspects (e.g., location, service of a hotel) and the relative weights reviewers have(More)
BACKGROUND Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown. METHODS To identify genetic loci conferring a risk(More)
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control(More)
Porcine circovirus type 2 (PCV2), the causative agent of postweaning multisystemic wasting syndrome (PMWS), is a serious economic problem for the swine industry in China. In this study, we investigated the genetic variation of PCV2 in China using strains isolated from 2004-2008. Viruses were isolated from samples collected from pigs with multi-systemic(More)
The explosion of Web opinion data has made essential the need for automatic tools to analyze and understand people's sentiments toward different topics. In most sentiment analysis applications, the sentiment lexicon plays a central role. However, it is well known that there is no universally optimal sentiment lexicon since the polarity of words is sensitive(More)