Yue-Loong Hsin

Learn More
In this paper, an 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, epileptic seizure detection, and adaptive feedback stimulation control. The SoC is composed of 8 energy-efficient analog front-end amplifiers (AFEAs), a 10b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor(More)
Determination of the volumes of acute cerebral infarct in the magnetic resonance imaging harbors prognostic values. However, semiautomatic method of segmentation is time-consuming and with high interrater variability. Using diffusion weighted imaging and apparent diffusion coefficient map from patients with acute infarction in 10 days, we aimed to develop a(More)
OBJECTIVE Repetitive seizures can alter the regulation of cardiac activity by the autonomic nervous system (ANS), and ANS dysregulation is thought to be associated with higher morbidity and mortality in epileptic patients, especially from sudden unexpected death. Few studies of interictal dysregulation of cardiac activity in children with epilepsy have been(More)
OBJECTIVE To identify autonomic dysregulation in frontal lobe epilepsy (FLE). METHODS We studied 14 male and 11 female subjects with FLE and an equal number of matched healthy control subjects. Lead I electrocardiograms were obtained for 5 min in the interictal state during daytime. Frequency-domain analysis of heart rate variability was performed and the(More)
Early Onset Parkinson's Disease (EOPD) is characterized by selective degeneration of nigrostriatal dopaminergic neurons and a marked response to levodopa. However, at present, few methods are available as diagnostic tools for EOPD except for 18F-DOPA PET. In addition, little is known about the correlation between clinical severity, neuroimaging grading and(More)
BACKGROUND Although many studies have found abnormalities in subcortical grey matter (GM) in patients with temporal lobe epilepsy or generalised epilepsies, few studies have examined subcortical GM in focal neocortical seizures. Using structural and tensor magnetic resonance imaging (MRI), we evaluated subcortical GM from patients with extratemporal lobe(More)
Focal cortical dysplasia (FCD) is a common disorder of cortical development that underlies the susceptibility of epileptogenicity of focal cortical region. However, FCD may not be visualized easily in regular MRI images by physicians, especially in the early stage. Hence, video-monitored EEGs are still the diagnosis gold standard in hospital. Based on fuzzy(More)
To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with(More)