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Determination of the volumes of acute cerebral infarct in the magnetic resonance imaging harbors prognostic values. However, semiautomatic method of segmentation is time-consuming and with high interrater variability. Using diffusion weighted imaging and apparent diffusion coefficient map from patients with acute infarction in 10 days, we aimed to develop a(More)
OBJECTIVE Repetitive seizures can alter the regulation of cardiac activity by the autonomic nervous system (ANS), and ANS dysregulation is thought to be associated with higher morbidity and mortality in epileptic patients, especially from sudden unexpected death. Few studies of interictal dysregulation of cardiac activity in children with epilepsy have been(More)
OBJECTIVE To identify autonomic dysregulation in frontal lobe epilepsy (FLE). METHODS We studied 14 male and 11 female subjects with FLE and an equal number of matched healthy control subjects. Lead I electrocardiograms were obtained for 5 min in the interictal state during daytime. Frequency-domain analysis of heart rate variability was performed and the(More)
In this paper, an 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, epileptic seizure detection, and adaptive feedback stimulation control. The SoC is composed of 8 energy-efficient analog front-end amplifiers (AFEAs), a 10b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor(More)
To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with(More)
BACKGROUND Although many studies have found abnormalities in subcortical grey matter (GM) in patients with temporal lobe epilepsy or generalised epilepsies, few studies have examined subcortical GM in focal neocortical seizures. Using structural and tensor magnetic resonance imaging (MRI), we evaluated subcortical GM from patients with extratemporal lobe(More)
White matter hyperintensities (WMHs) of presumed vascular origin are common in ageing population, especially in patients with acute cerebral infarction and the volume has been reported to be associated with mental impairment and the risk of hemorrhage from antithrombotic agents. WMHs delineation can be computerized to minimize human bias. However, the(More)
Mapping the electric field of the brain with electrodes benefits from its superior temporal resolution but is prone to low spatial resolution property comparing with other modalities such as fMRI, which can directly impact the precision of clinical diagnosis. Simulations show that dense arrays with straightforwardly miniaturized electrodes in terms of size(More)
Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures, This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the(More)