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N(6)-methyladenosine (m(6)A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes. m(6)A modification is involved in cell fate determination in yeast and embryo development in plants. Its mammalian function remains unknown but thousands of mammalian mRNAs and long non-coding RNAs (lncRNAs) show m(6)A modification and(More)
AIMS microRNA (miRNA) is reported to be present in the blood of humans and has been increasingly suggested as a biomarker for diseases. We aim to determine the potential of cardiac-specific miRNAs in circulation to serve as biomarkers for acute myocardial infarction (AMI). METHODS AND RESULTS By verifying their tissue expression patterns with real-time(More)
The exponential growth in the amount of genomic data has spurred growing interest in large scale analysis of genetic information. Bioinformatics applications, which explore computational methods to allow researchers to sift through the massive biological data and extract useful information, are becoming increasingly important computer workloads. This paper(More)
BACKGROUND Better methods of assessing patients' and family members' causal models of illness are needed to improve adherence with biomedical interventions and to design services that meet the needs of consumers. AIMS To develop a quantitative measure suitable for assessing the relationship of causal beliefs to expressed emotion, stigma, care-seeking and(More)
BACKGROUND There is much uncertainty about the effects of early lowering of elevated blood pressure (BP) after acute intracerebral haemorrhage (ICH). Our aim was to assess the safety and efficiency of this treatment, as a run-in phase to a larger trial. METHODS Patients who had acute spontaneous ICH diagnosed by CT within 6 h of onset, elevated systolic(More)
The last few years have seen the use of photo response non-uniformity noise (PRNU), a unique fingerprint of imaging sensors, in various digital forensic applications such as source device identification, content integrity verification and authentication. However, the use of a colour filter array for capturing only one of the three colour components per(More)
The exponential growth in the amount of genomic data has spurred growing interest in large scale analysis of genetic information. Bioinformatics applications, which explore computational methods to allow researchers to sift through the massive biological data and extract useful information, are becoming increasingly important computer workloads. This paper(More)
—Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated, protein kinase A– dependent local subsarcolemmal ryanodine receptor Ca 2ϩ releases (LCRs). LCRs activated an inward Na ϩ /Ca 2ϩ exchange current that increases the terminal diastolic depolarization rate and, therefore, the spontaneous SANC beating rate. Basal cAMP(More)
CONTEXT Total hip arthroplasty is a common surgical procedure but little is known about longitudinal trends. OBJECTIVE To examine demographics and outcomes of patients undergoing primary and revision total hip arthroplasty. DESIGN, SETTING, AND PARTICIPANTS Observational cohort of 1,453,493 Medicare Part A beneficiaries who underwent primary total hip(More)
The ribonuclease (RNase) H class of enzymes degrades the RNA component of RNA:DNA hybrids and is important in nucleic acid metabolism. RNase H2 is specialized to remove single ribonucleotides [ribonucleoside monophosphates (rNMPs)] from duplex DNA, and its absence in budding yeast has been associated with the accumulation of deletions within short tandem(More)