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We introduce a novel algorithm to reconstruct dynamic magnetic resonance imaging (MRI) data from under-sampled k-t space data. In contrast to classical model based cine MRI schemes that rely on the sparsity or banded structure in Fourier space, we use the compact representation of the data in the Karhunen Louve transform (KLT) domain to exploit the(More)
Nicastrin is genetically linked to Notch/lin-12 signaling in C. elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants. Nic mutants and tissue clones display characteristic Notch-like phenotypes. Genetic and inhibitor studies indicate a function for(More)
Yeast genetics and in vitro biochemical analysis have identified numerous genes involved in protein secretion. As compared with yeast, however, the metazoan secretory pathway is more complex and many mechanisms that regulate organization of the Golgi apparatus remain poorly characterized. We performed a genome-wide RNA-mediated interference screen in a(More)
Internet clouds work as service factories built around web-scale datacenters. The elastic cloud resources and huge datasets processed are subject to security breaches, privacy abuses, and copyright violations. Provisioned cloud resources on-demand are especially vulnerable to cyber attacks. The cloud platforms built by Google, IBM, and Amazon all reveal(More)
Aimed at the situation that it is difficult to detect the peer-to-peer (P2P) botnet, we provide a new method for detection based on the analysis network streams. Firstly, because the P2P streams reveal the characteristics of paroxysm and distribution, we can filtrate them with streams feature for our targets to analyze. Then, according to the cohesion in a(More)
We introduce novel image regularization penalties to overcome the practical problems associated with the classical total variation (TV) scheme. Motivated by novel reinterpretations of the classical TV regularizer, we derive two families of functionals involving higher degree partial image derivatives; we term these families as isotropic and anisotropic(More)
he ␥-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative ␥-secretase components have been identified—presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we use a stepwise coexpression approach to investigate the(More)
N-Methyl-D-aspartate (NMDA) receptor (NMDAR) activation and downstream signaling are important for neuronal function. Activation of prosurvival Src family kinases and extracellular signal-regulated kinase (ERK) 1/2 is initiated by NMDAR activation, but the cellular organization of these kinases in relation to NMDARs is not entirely clear. We hypothesized(More)
K(+) channels play essential roles in regulating membrane excitability of many diverse cell types by selectively conducting K(+) ions through their pores. Many diverse molecules can plug the pore and modulate the K(+) current. Quaternary ammonium (QA) ions are a class of pore blockers that have been used for decades by biophysicists to probe the pore,(More)