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A three-dimensional (3D) linear model for digital breast tomosynthesis (DBT) was developed to investigate the effects of different imaging system parameters on the reconstructed image quality. In the present work, experimental validation of the model was performed on a prototype DBT system equipped with an amorphous selenium (a-Se) digital mammography(More)
Digital breast tomosynthesis (DBT) is a three-dimensional (3D) x-ray imaging modality that reconstructs image slices parallel to the detector plane. Image acquisition is performed using a limited angular range (less than 50 degrees) and a limited number of projection views (less than 50 views). Due to incomplete data sampling, image artifacts are(More)
PURPOSE Substantial effort has been devoted to the clinical development of digital breast tomosynthesis (DBT). DBT is a three-dimensional (3D) x-ray imaging modality that reconstructs a number of thin image slices parallel to a stationary detector plane. Preliminary clinical studies have shown that the removal of overlapping breast tissue reduces image(More)
PURPOSE Contrast-enhanced (CE) breast imaging involves the injection contrast agents (i.e., iodine) to increase conspicuity of malignant lesions. CE imaging may be used in conjunction with digital mammography (DM) or digital breast tomosynthesis (DBT) and has shown promise in improving diagnostic specificity. Both CE-DM and CE-DBT techniques require(More)
PURPOSE To develop and validate a Monte Carlo (MC) model of a novel multi-layer imager (MLI) for megavolt (MV) energy beams. The MC model will enable performance optimization of the MLI design for clinical applications including patient setup verification, tumor tracking and MVCBCT. METHODS The MLI is composed of four layers of converter, scintillator and(More)
PURPOSE A novel Megavoltage (MV) multilayer imager (MLI) design featuring higher detective quantum efficiency and lower noise than current conventional MV imagers in clinical use has been recently reported. Optimization of the MLI design for multiple applications including tumor tracking, MV-CBCT and portal dosimetry requires a computational model that will(More)
Contrast-enhanced dual energy digital breast tomosynthesis (CE-DE-DBT) is designed to image iodinated masses while suppressing breast anatomical background. Scatter is a problem, especially for high energy acquisition, in that it causes severe cupping artifact and iodine quantitation errors. We propose a patient specific scatter correction (SC) algorithm(More)