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A Cu/Pd-catalyzed, three-component click reaction of azide, alkyne, and aryl halide has been developed. By using this Cu/Pd transmetalation relay catalysis, a variety of 1,4,5-trisubstituted 1,2,3-triazoles were quickly assembled in one step in high yields with complete regioselectivity, just like assembling Lego bricks. Notably, different from the… (More)
A new lanthanide-sensitized luminescence system: europium-sparfloxacin-1,10-phenanthroline-sodium dodecyl sulfate has been discovered. The spectrofluorimetric properties of the system were studied. The effect of experimental conditions on the fluorescence intensity was defined. Under the optimum conditions, the fluorescence intensity of the system is a… (More)
[reaction: see text] A highly efficient catalytic borylation process with aryldiazonium ions was developed using a carbene-palladium catalyst formed in situ to give arylpinacolatoborane products. An X-ray structure for the N-heterocyclic carbene-palladium complex, used as the catalyst formed from bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium chloride,… (More)
[structure: see text] Bulky phenanthracenyl imidazolium-derived carbene ligands were investigated for copper-free Sonogashira coupling with terminal acetylenes. Aryl bromides and iodides gave coupled products in excellent yields from the Pd(PPh(3))(2)Cl(2) complex with potassium t-butoxide and 18-crown-6 in THF. A remarkable dependence on the size of the… (More)
Metalated triazoles are the key reactive intermediate of the current click reaction (CuAAC). Bench-stable 5-stannyl triazoles are obtained by a copper-catalyzed interrupted click reaction of easily available terminal alkynes. Subsequent palladium-catalyzed cross-coupling reactions, electrophilic trifluoromethylthiolation and trifluoromethylation, generate… (More)
The title compound, C(36)H(36)Br(2)O(3), was synthesized from (R(p))-4-bromo-12-hy-droxy[2.2]paracyclo-phane and oxydiethane-2,1-diyl bis-(4-methyl-benzene-sulfonate). The crystal packing exhibits a short O⋯Br inter-action [Br⋯O = 3.185 (3) Å] and a weak inter-molecular C-H⋯O contact.
A new planar and centrally chiral bicyclic 1,2,4-triazolium salt has been synthesized from [2.2]paracyclophane and phenylglycinol. The N-heterocyclic carbene (NHC) copper(I) complex generated in situ by the reaction of the triazolium salt and Cu(2)O was an efficient catalyst for the asymmetric β-boration of acyclic enones, producing β-boryl ketones in high… (More)
The first example of transition metal-free enantioselective 1,2-silylation of aromatic aldehydes is reported. This protocol enables an easy access to chiral α-hydroxysilanes from readily available aromatic aldehydes.
A novel series of p-terphenyl derivatives (1-4, 1a-4a) was successfully synthesized and their in vitro anticancer activities were evaluated. Compound 1, showing the best antiproliferative activity with IC50<1 μM against MDA-MB-435 cells, was further investigated. Compound 1 brought about a remarkable accumulation of MDA-MB-435 cells in G2/M phase prior to… (More)