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BMP4 signaling is involved in the generation of inner ear sensory epithelia
BackgroundThe robust expression of BMP4 in the incipient sensory organs of the inner ear suggests possible roles for this signaling protein during induction and development of auditory and vestibular… Expand
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.
Mechanisms of bile acid-induced (BA-induced) liver injury in cholestasis are controversial, limiting development of new therapies. We examined how BAs initiate liver injury using isolated liver cells… Expand
Preparation of Quantum Dot/Drug Nanoparticle Formulations for Traceable Targeted Delivery and Therapy
Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy… Expand
A Versatile Agrobacterium-Mediated Transient Gene Expression System for Herbaceous Plants and Trees
- L. Zheng, G. Liu, Xiangnan Meng, Yanbang Li, Yucheng Wang
- Biology, Medicine
- Biochemical Genetics
- 20 May 2012
Plant transient expression is a powerful method used widely for the functional characterization of genes and protein production. In comparison with stable transformation, it has the advantages of… Expand
Cytotoxicity assessment of functionalized CdSe, CdTe and InP quantum dots in two human cancer cell models.
- J. Liu, Rui Hu, +7 authors K. Yong
- Medicine, Materials Science
- Materials science & engineering. C, Materials for…
- 1 December 2015
The toxicity of quantum dots (QDs) has been extensively studied over the past decade. Some common factors that originate the QD toxicity include releasing of heavy metal ions from degraded QDs and… Expand
Rational design of multimodal and multifunctional InP quantum dot nanoprobes for cancer: in vitro and in vivo applications
In this paper we report the development of multifunctional nanoprobes based on InP–ZnS quantum dots (QDs) for high contrast multimodal imaging and other applications for cancer in vitro and in vivo.… Expand
Biodegradable nanocapsules as siRNA carriers for mutant K-Ras gene silencing of human pancreatic carcinoma cells.
The application of small interfering RNA (siRNA)-based RNA interference (RNAi) for cancer gene therapy has attracted great attention. Gene therapy is a promising strategy for cancer treatment because… Expand
Synthesis and Characterization of Mn:ZnSe/ZnS/ZnMnS Sandwiched QDs for Multimodal Imaging and Theranostic Applications.
- Yucheng Wang, Bo Chen Wu, Chengbin Yang, Maixian Liu, Tze Chien Sum, Ken-Tye Yong
- Medicine, Materials Science
In this work, a facile aqueous synthesis method is optimized to produce Mn:ZnSe/ZnS/ZnMnS sandwiched quantum dots (SQDs). In this core-shell co-doped system, paramagnetic Mn(2+) ions are introduced… Expand
Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
In this work, we demonstrate the use of manganese doped zinc selenide QDs (Mn:ZnSe d-dots) for gene delivery in vitro. Specifically, the d-dots were prepared as nanoplexes for facilitating the… Expand
Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells
RNA interfering (RNAi) using short interfering RNA (siRNA) is becoming a promising approach for cancer gene therapy. However, owing to the lack of safe and efficient carriers, the application of RNAi… Expand