Learn More
Loss of neurons after brain injury and in neurodegenerative disease is often accompanied by reactive gliosis and scarring, which are difficult to reverse with existing treatment approaches. Here, we show that reactive glial cells in the cortex of stab-injured or Alzheimer's disease (AD) model mice can be directly reprogrammed into functional neurons in vivo(More)
Renewable and clean "green" electronics based on paper substrates is an emerging field with intensifying research and commercial interests, as the technology combines the unique properties of flexibility, cost efficiency, recyclability, and renewability with the lightweight nature of paper. Because of its excellent optical transmittance and low surface(More)
BACKGROUND Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized platform used to detect alternative splicing on a genome-wide scale. Two probe summarization algorithms, PLIER (Probe Logarithmic Intensity Error) and RMA (Robust Multichip Average),(More)
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 different plants used for the treatment of toxicity were screened for their in vivo protective effects. Flies were fed a standard cornmeal-yeast medium (control group) or the standard medium containing medicinal plant extracts (experimental(More)
—In order to study the power frequency electric field of UHV AC transmission lines, this paper which models and calculates using boundary element method simulates various factors influencing the distribution of the power frequency electric field, such as the conductor arrangement, the over-ground height, the split spacing and the sub conductor radius.(More)
There has been a recent interest in the broader physiological importance of multispecific "drug" transporters of the SLC and ABC transporter families. Here, a novel multi-tiered systems biology approach was used to predict metabolites and signaling molecules potentially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6,(More)
RÉSUMÉ : Dans une perspective d'individualisation autonomisante, nous proposons d'analyser la prise en compte du sujet apprenant dans la conception du scénario pédagogique (SP) à distance. Le cadre théorique articulant des travaux portant sur les dispositifs de formation à distance et sur la pédagogie individualisée repose sur trois dimensions pour répondre(More)
Statistical analysis was performed on physicochemical descriptors of ∼250 drugs known to interact with one or more SLC22 "drug" transporters (i.e., SLC22A6 or OAT1, SLC22A8 or OAT3, SLC22A1 or OCT1, and SLC22A2 or OCT2), followed by application of machine-learning methods and wet laboratory testing of novel predictions. In addition to molecular charge,(More)