Loss of neurons after brain injury and in neurodegenerative disease is often accompanied by reactive gliosis and scarring, which are difficult to reverse with existing treatment approaches. Here, we show that reactive glial cells in the cortex of stab-injured or Alzheimer's disease (AD) model mice can be directly reprogrammed into functional neurons in vivo… (More)
Renewable and clean "green" electronics based on paper substrates is an emerging field with intensifying research and commercial interests, as the technology combines the unique properties of flexibility, cost efficiency, recyclability, and renewability with the lightweight nature of paper. Because of its excellent optical transmittance and low surface… (More)
BACKGROUND Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized platform used to detect alternative splicing on a genome-wide scale. Two probe summarization algorithms, PLIER (Probe Logarithmic Intensity Error) and RMA (Robust Multichip Average),… (More)
PURPOSE The ability to determine the spatial and metabolic distribution of prostate cancer is essential in assessing initial stage, prognosis, and treatment efficacy. Current markers of tumor progression such as prostate-specific antigen (PSA) do not provide spatial information about tumor extent or regions of high metabolic activity. EXPERIMENTAL DESIGN… (More)
If a no-load transformer is switch on or switch off, or in the period of voltage recovery when suffered from an external fault, a big excitation inrush current will appear in transformer windings, this may lead to the damage of the device, and bring impact to power grid, sometimes it will make the differential protection of the transformer misoperation.… (More)
According to the parasitic parameter which was produced by the PCB line of MOSFET's driving circuit, this paper will analyze the circuit principle of driving circuit, and then uses the software Saber to stimulate the circuit, finally verifies the stimulate results and formula under the experimental waveforms and statics.