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Numerical modeling of the human cardiovascular system has always been an active research direction since the 19th century. In the past, various simulation models of different complexities were proposed for different research purposes. In this paper, an improved numerical model to study the dynamic function of the human circulation system is proposed. In the(More)
This paper presents a new concentrated parameter model for cardiovascular dynamics that includes an innovative model of heart valve dynamics, which is embedded in the overall model of the four chambers of the heart and the systemic and pulmonary circulation loops. The heart chambers are described with a variable elastance model, and the systemic and(More)
BACKGROUND Zero-dimensional (lumped parameter) and one dimensional models, based on simplified representations of the components of the cardiovascular system, can contribute strongly to our understanding of circulatory physiology. Zero-D models provide a concise way to evaluate the haemodynamic interactions among the cardiovascular organs, whilst one-D(More)
This study presents a numerical simulation of cardiovascular response in the heart failure condition under the support of a Berlin Heart INCOR impeller pump-type ventricular assist device (VAD). The model is implemented using the CellML modelling language. To investigate the potential of using the Berlin Heart INCOR impeller pump to produce physiologically(More)
Predicting hemodynamics in native and residual coarctation: preliminary results of a Rigid-Wall Computational-Fluid-Dynamics model (RW-CFD) validated against clinically invasive pressure measures at rest and during pharmacological stress Israel Valverde, Cristina Staicu, Heynric Grotenhuis, Alberto Marzo, Kawal Rhode, Yubing Shi, Alistair G Brown, Aphrodite(More)
State of the art simulations of aortic haemodynamics feature full fluid-structure interaction (FSI) and coupled 0D boundary conditions. Such analyses require not only significant computational resource but also weeks to months of run time, which compromises the effectiveness of their translation to a clinical workflow. This article employs three(More)
There is significant interest in the development and application of variable speed impeller-pump type ventricular assist devices designed to generate pulsatile blood flow. However, no study has so far been carried out to investigate the systemic cardiovascular response to various aspects of pump motion. In this article, a numerical model is constructed for(More)
We report the first attempt to study with numerical methods ventricular assist device (VAD) models and the effects of various inlet VAD cannulations, coupling physical explanations and numerical investigation conclusions with clinical research results. We compared the hemodynamic response with VAD support by using two distinct VAD-inlet cannulation(More)
The anatomy and motion of the heart and the aorta are essential for patient-specific simulations of cardiac electrophysiology, wall mechanics and hemodynamics. Within the European integrated project euHeart, algorithms have been developed that allow to efficiently generate patient-specific anatomical models from medical images from multiple imaging(More)
BACKGROUND AND AIM OF THE STUDY Most previous computational fluid dynamics (CFD) studies of blood flow in mechanical heart valves (MHVs) have not efficiently addressed the important features of moving leaflet and blood-leaflet interaction. Herein, computationally efficient approaches were developed to study these features and to obtain better insight into(More)