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Radical Alkynyltrifluoromethylation of Alkenes Initiated by an Electron Donor-Acceptor Complex.
A variety ofAlkenes are compatible in this protocol including aliphatic alkenes, vinyl ethers, enecarbamates, styrenes, and even acrylates, providing diverse β- trifluoromethyl alkynes in good to excellent yields.
Direct Aromatic C-H Trifluoromethylation via an Electron-Donor-Acceptor Complex.
The radical-based methodology presented here allows to access highly-functionalized trifluoromethyl arenes in up to 81 % chemical yield.
Synthesis of 6-alkylated phenanthridine derivatives using photoredox neutral somophilic isocyanide insertion.
The first example of photoredox neutral, somophilic isocyanide insertions is reported, which provide 6-alkylated phenanthridine derivatives under mild reaction conditions and is considered to be a new synthetic protocol which circumvents the use of stoichiometric oxidants and harsh reaction conditions.
Sulfonation and Trifluoromethylation of Enol Acetates with Sulfonyl Chlorides Using Visible-Light Photoredox Catalysis
A mild, practical method to prepare α-sulfonyl and α-trifluoromethyl ketones from readily available enol acetates and sulfonyl chlorides has been developed using visible-light photoredox catalysis.
Hydrotrifluoromethylation of Unactivated Alkenes and Alkynes Enabled by an Electron-Donor-Acceptor Complex of Togni's Reagent with a Tertiary Amine.
An electron-donor-acceptor (EDA) complex between Togni's reagent and a tertiary amine has been introduced and the hydrotrifluoromethylation of unactivated aliphatic alkenes and alkynes enabled by this EDA complex has been developed.
Isocyanide insertion: de novo synthesis of trifluoromethylated phenanthridine derivatives.
A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion
De novo synthesis of polysubstituted naphthols and furans using photoredox neutral coupling of alkynes with 2-bromo-1,3-dicarbonyl compounds.
A conceptually new strategy has been described for the mild, practical, and environmentally friendly preparation of naphthols and furans using a visible-light promoted photoredox neutral approach.
Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts.
The methodology presented here represents the first example of isoquinoline synthesis via somophilic isocyanide insertion, and it is claimed that this synthesis is the first of its kind.
Visible-light-promoted and photocatalyst-free trifluoromethylation of enamides
An efficient and practical method is developed for the trifluoromethylation of enamides using Umemoto’s reagent as the trifluoromethylating reagent. These reactions proceeded under visible light