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Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in Mice*
TLDR
Ameloblast-specific expression of enamelin is demonstrated and it is revealed that enamin is essential for proper enamel matrix organization and mineralization. Expand
Hypomaturation Enamel Defects in Klk4 Knockout/LacZ Knockin Mice*
TLDR
Results demonstrate that Klk4 is essential for the removal of enamel proteins and the proper maturation ofEnamel crystals and an important finding was that individual enamel crystallites of erupted teeth failed to grow together, interlock, and function as a unit. Expand
FAM20A Mutations Can Cause Enamel-Renal Syndrome (ERS)
TLDR
FAM20A, which has a kinase homology domain and localizes to the Golgi, is a putative Golgi kinase that plays a significant role in the regulation of biomineralization processes, and that mutations in FAM20A cause both AIGFS and ERS. Expand
Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.
TLDR
An important role is portrayed for Bcl-x(L) as a key factor associated with chemotherapy failure in the treatment of ovarian cancer. Expand
Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis.
TLDR
A novel mechanism by which UV light regulates early phase NFkappaB activation by means of an ER-stress-induced translational inhibition pathway is proposed. Expand
Consequences for enamel development and mineralization resulting from loss of function of ameloblastin or enamelin.
TLDR
These findings confirm that both ameloblastin and enamelin are required by ameloblasts to create an enamel layer by appositional growth as well as to assist in achieving its unique high level of mineralization. Expand
Ultraviolet Light Inhibits Translation through Activation of the Unfolded Protein Response Kinase PERK in the Lumen of the Endoplasmic Reticulum*
TLDR
It is shown that UV irradiation induces phosphorylation of eukaryotic translation initiation factor 2 on the α-subunit (eIF2α) and inhibits protein synthesis in a dosage- and time-dependent manner and supports a novel mechanism by whichUV irradiation regulates translation via an endoplasmic reticulum-stress signaling pathway. Expand
Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds
TLDR
It is concluded that molar crown and root dysmorphologies are caused by Wnt10A defects and that the severity of the tooth agenesis correlates with the number of defective WNT10A alleles. Expand
Effect of Kallikrein 4 Loss on Enamel Mineralization
TLDR
Investigation of changes in enamel mineralization occurring in mice unable to produce kallikrein 4 (Klk4), a proteinase associated with terminal extracellular degradation of matrix proteins during the maturation stage reaffirm the importance of secreted proteinases to enamel Mineral acquisition. Expand
Maturation stage enamel malformations in Amtn and Klk4 null mice.
TLDR
It is concluded that AMTN and KLK4 function independently, but are both necessary for proper enamel maturation. Expand
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