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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
Significance T-cell activation requires the translation of antigen binding to the T-cell receptor (TCR) into intracellular signaling. However, how antigen recognition and signal transduction areExpand
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Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development
Bone morphogenetic proteins (Bmps) control dorsoventral patterning of vertebrate embryos through the establishment of a ventrodorsal gradient of the activated downstream cytoplasmic effectorsExpand
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Introducing Membrane Charge and Membrane Potential to T Cell Signaling
While membrane models now include the heterogeneous distribution of lipids, the impact of membrane charges on regulating the association of proteins with the plasma membrane is often overlooked.Expand
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FSCS Reveals the Complexity of Lipid Domain Dynamics in the Plasma Membrane of Live Cells
The coexistence of lipid domains with different degrees of lipid packing in the plasma membrane of mammalian cells has been postulated, but direct evidence has so far been challenging to obtainExpand
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Status of Macrobenthic Community and Its Relationships to Trace Metals and Natural Sediment Characteristics
Laizhou Bay, located in the northwest of Shandong Peninsula, has complex transitional environments between terrestrial and marine ecosystems. In the present study, a total of 122, 131, and 139Expand
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SCINA: Semi-Supervised Analysis of Single Cells in silico
Advances in single-cell RNA sequencing (scRNA-Seq) have allowed for comprehensive analyses of single cell data. However, current analyses of scRNA-Seq data usually start from unsupervised clusteringExpand
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Self-calibrated line-scan STED-FCS to quantify lipid dynamics in model and cell membranes.
Only a limited number of noninvasive techniques are available to directly measure the dynamic behavior of lipids in model and cell membranes. Here, we explored whether a commercial instrument couldExpand
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A FRET sensor enables quantitative measurements of membrane charges in live cells
Membrane charge has a critical role in protein trafficking and signaling. However, quantification of the effective electrostatic potential of cellular membranes has remained challenging. We developedExpand
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Nanodomains in biological membranes.
Lipid rafts are defined as cholesterol- and sphingomyelin-enriched membrane domains in the plasma membrane of cells that are highly dynamic and cannot be resolved with conventional light microscopy.Expand
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An intermolecular FRET sensor detects the dynamics of T cell receptor clustering
Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. HereExpand
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