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We present a modular approach for analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity from the slow dynamics of the calcium indicator. Our approach relies on a constrained nonnegative(More)
A body of recent work in modeling neural activity focuses on recovering lowdimensional latent features that capture the statistical structure of large-scale neural populations. Most such approaches have focused on linear generative models, where inference is computationally tractable. Here, we propose fLDS, a general class of nonlinear generative models(More)
Latent factor models have been widely used to analyze simultaneous recordings of spike trains from large, heterogeneous neural populations. These models assume the signal of interest in the population is a low-dimensional latent intensity that evolves over time, which is observed in high dimension via noisy point-process observations. These techniques have(More)
OBJECTIVE Gastric cancer can present as an exophytic lesion, diffuse infiltration of the gastric mucosa or even as a gastric ulcer, which can mimic a benign gastric ulcer. The purpose of this study was to evaluate the value of endoscopic ultrasound (EUS) in the differential diagnosis between benign and malignant gastric ulcer. MATERIAL AND METHODS 176(More)
Maximum entropy modeling is a flexible and popular framework for formulating statistical models given partial knowledge. In this paper, rather than the traditional method of optimizing over the continuous density directly, we learn a smooth and invertible transformation that maps a simple distribution to the desired maximum entropy distribution. Doing so is(More)
The aim of this study is to examine the effect and mechanism of a selective cyclooxygenase-2 (COX-2) inhibitor NS-398 on inducing apoptosis of esophageal cancer cells. After the treatment with NS-398 on esophageal carcinoma EC9706 cell, MTT assay was used to observe the inhibition of EC9706 cell growth and apoptosis was determined by electronic microscopy(More)
Unlike breast cancer that is positive for estrogen receptor-α (ERα), there are no targeted therapies for triple-negative breast cancer (TNBC). ERα is silenced in TNBC through epigenetic changes including DNA methylation and histone acetylation. Restoring ERα expression in TNBC may sensitize patients to endocrine therapy. Expression of c-Src and ERα are(More)
We present a structured matrix factorization approach to analyzing calcium imaging recordings of large neuronal ensembles. Our goal is to simultaneously identify the locations of the neurons, demix spatially overlapping components, and denoise and deconvolve the spiking activity of each neuron from the slow dynamics of the calcium indicator. The matrix(More)
Injury or neurodegenerative disorders of the enteric nervous system (ENS) cause gastrointestinal dysfunctions for which there is no effective therapy. This study, using the benzalkonium chloride-induced rat gastric denervation model, aimed to determine whether transplantation of bone marrow-derived mesenchymal stem cells (BMSC) could promote ENS neuron(More)
There exist an elliptical confidence region for the w, as described in the following theorem Theorem 1. ([2], Theorem 2) Assuming ‖w‖ ≤ √ d and ‖xt‖ ≤ √ d, with probably 1− δ, we have w ∈ Ct, where Ct = { z : ‖z − ŵt‖Mt ≤ 2 √ d log Td δ } For any x ∈ A, we define UCBx,t = maxz∈Ct z′x if w ∈ Ct (which holds with high probability). At each time, the UCB(More)
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