Learn More
Computer scientists are always eager to have a powerful, robust and stable compiler infrastructure. However, until recently, researchers had to either use available and often unstable research compilers , create new ones from scratch, try to hack open-source non-research compilers or use source to source tools. It often requires duplication of a large(More)
While iterative optimization has become a popular compiler optimization approach, it is based on a premise which has never been truly evaluated: that it is possible to learn the best compiler optimizations across data sets. Up to now, most iterative optimization studies find the best optimizations through repeated runs on the same data set. Only a handful(More)
Iterative optimization is a popular compiler optimization approach that has been studied extensively over the past decade. In this article, we deconstruct iterative optimization by evaluating whether it works across datasets and by analyzing why it works. Up to now, most iterative optimization studies are based on a premise which was never truly evaluated:(More)
A systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in the present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, and exiting the cells, respectively. Most of the NPs are found to be enclosed in membrane bounded organelles, which are fairly stable (against rupture) as(More)
Castration-resistant prostate cancer (CRPC) is the main challenge for prostate cancer treatment. Recent studies have indicated that extending the treatments to simultaneously targeting different pathways could provide better approaches. To better understand the regulatory functions of different pathways, a system-wide study of CRPC regulation is necessary.(More)
We disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO(2) nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to(More)
Because of tight power and energy constraints, industry is progressively shifting toward <i>heterogeneous</i> system-on-chip (SoC) architectures composed of a mix of general-purpose cores along with a number of accelerators. However, such SoC architectures can be very challenging to efficiently program for the vast majority of programmers, due to numerous(More)
Scaffold-based tumor engineering is rapidly evolving the study of cancer progression. However, the effects of scaffolds and environment on tumor formation have seldom been investigated. In this study, four types of injectable hydrogels, namely, collagen type I, Matrigel, alginate and agarose gels, were loaded with human ovarian cancer SKOV3 cells and then(More)
Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between(More)