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The mechanism of sevoflurane preconditioning-induced neuroprotection is poorly understood. This study was aimed at identifying microRNAs (miRNAs) involved in the protective effect of sevoflurane preconditioning against hypoxic injury using the miRCURYTM LNA Array. The screened differentially expressed miRNAs were further validated using qRT-PCR. Finally,(More)
Groundwater long-term monitoring (LTM) is required to assess human health and environmental risk of residual contaminants after active groundwater remediation activities are completed. However, LTM can be costly because of the large number of sampling locations that exist at a site from previous site characterization and remediation activities. The cost of(More)
Propofol is a common clinically used intravenous anaesthetic agent with antioxidative property. It has been thought to have neuroprotection in vitro and in vivo. However, the underlying mechanisms remain unclear. Endoplasmic reticulum (ER) stress plays an important role in regulating the signaling pathways concerning cell death and survival. Therefore, we(More)
Tramadol is an analgesic drug and relieves pain through activating μ-opioid receptors and inhibiting serotonin and noradrenaline reuptake. Emerging evidence shows that it also stimulates immune cells, including NK cells, splenocytes, and lymphocytes, and elevates IL-2 production. However, it remains unknown whether and how tramadol directly affects(More)
Increasing studies have demonstrated that sevoflurane can induce neurotoxicity in the developing brains. JNK normally promotes apoptosis. It was hypothesized that sevoflurane affected the proliferation and differentiation of FNSCs and induced cell apoptosis, which caused the learning and memory deficits via JNK pathway. Sevoflurane at a concentration of(More)
Groundwater long-term monitoring (LTM) is required to assess the performance of groundwater remediation and human being health risk at post-closure sites where groundwater contaminants are still present. The large number of sampling locations, number of constituents to be monitored, and the frequency of the sampling make the LTM costly, especially since LTM(More)
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