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Notch signaling is essential for vascular morphogenesis in mice.

• Luke T. Krebs, Yuanchao Xue, +10 authors Thomas Gridley
• Genes & development
• 2000

The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated… (More)

Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis

• Lan-tao Gou, Peng Dai, +16 authors Mo-fang Liu
• Cell Research
• 2015

Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure.

• Chaoliang Wei, Jinsong Qiu, +10 authors X. D. Fu
• Cell reports
• 2015

Heart failure is characterized by the transition from an initial compensatory response to decompensation, which can be partially mimicked by transverse aortic constriction (TAC) in rodent models.… (More)

Sequential Regulatory Loops as Key Gatekeepers for Neuronal Reprogramming in Human Cells

• Yuanchao Xue, Heng Qian, +6 authors X. D. Fu
• Nature Neuroscience
• 2016

Direct conversion of somatic cells into neurons holds great promise for regenerative medicine. However, neuronal conversion is relatively inefficient in human cells compared to mouse cells. It has… (More)

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

• Su Min Lim, Won Jun Choi, +12 authors Seung Hyun Kim
• Molecular Neurodegeneration
• 2016

Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS… (More)

Repression of the Central S plicing Regulator RBFox 2 Is Functionally Linked to Pressure Overload-Induced Heart Failure Graphical

• Chaoliang Wei, Jinsong Qiu, +10 authors Xiang-Dong Fu
• 2015

Patient fibroblasts-derived induced neurons demonstrate autonomous neuronal defects in adult-onset Krabbe disease

• Su Min Lim, Byung-Ok Choi, +11 authors Seung Hyun Kim
• Oncotarget
• 2016

Krabbe disease (KD) is an autosomal recessive neurodegenerative disorder caused by defective β-galactosylceramidase (GALC), a lysosomal enzyme responsible for cleavage of several key substrates… (More)

PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation.

• Gabriela C Coutinho-Mansfield, Yuanchao Xue, Yi Zhang, Xiang-Dong Fu
• Genes & development
• 2007

Neuronal differentiation involves extensive reprogramming of gene expression. Many neuronal-specific genes are actively repressed in nonneuronal cells, while many others are induced in response to… (More)

Drebrin, a development-associated brain protein from rat embryo, causes the dissociation of tropomyosin from actin filaments.

• Ryoki Ishikawa, Kanehiro Hayashi, +4 authors Kazuhiro Kohama
• The Journal of biological chemistry
• 1994

Drebrin is a development-associated neuroprotein whose cDNA into fibroblasts causes the formation of dendrite-like structures (Shirao, T., Kojima, N., and Obata, K. (1992) Neuroreport 3, 109-112). To… (More)

Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.

• Zhiqiang Cai, Ran Cao, +5 authors X. D. Fu
• The Journal of biological chemistry
• 2015

MicroRNAs (miRs) are a class of small regulatory RNAs that have been implicated in diverse biological pathways, including cancer. miR-17/20a encoded by the c13orf25 locus is among the first miRs… (More)

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