Yuan-chin Ivan Chang

Learn More
The Dietary Approaches to Stop Hypertension (DASH) diet has been proven to effectively lower blood pressure(BP), and associate with a lower cardiovascular disease and stroke risk in mainly non-Asians. Further, it is unclear if adhering to the DASH target nutrients has similar BP impact as adhering to the recommended DASH food groups. Associations between(More)
MOTIVATION Protein expression profiling for differences indicative of early cancer holds promise for improving diagnostics. Due to their high dimensionality, statistical analysis of proteomic data from mass spectrometers is challenging in many aspects such as dimension reduction, feature subset selection as well as construction of classification rules.(More)
OBJECTIVE To study the association between endocrine disturbances and metabolic complications in women seeking gynecologic care. DESIGN Retrospective study, cluster analysis. SETTING Outpatient clinic, university medical center. PATIENT(S) 573 women, including 384 at low risk and 189 at high risk of cardiometabolic disease. INTERVENTION(S) None. (More)
AIM The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS). DESIGN This was a retrospective study. PATIENTS Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated. MAIN OUTCOME MEASURE(S) Insulin resistance and the(More)
FDA reviewers need a means to rapidly predict organ-specific carcinogenicity to aid in evaluating new chemicals submitted for approval. This research addressed the building of a database to use in developing a predictive model for such an application based on structure-activity relationships (SAR). The Internet availability of the Carcinogenic Potency(More)
A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding an ideal biomarker is not easy and combining multiple biomarkers provides a promising alternative. Moreover, some biomarkers based on the optimal linear combination do not have enough discriminatory power. As a result, the aim of this study was to find the(More)
OBJECTIVE To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. STUDY DESIGN Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index -(More)