Yuan-cheng Li

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The proliferation of neonatal Schwann cells (SCs) in response to mitogenic agents has been well analyzed in vitro (mono-layer-culture method, 2D environment), but not in vivo (3D environment). To assess the mitogenic effect of platelet-derived growth factors-BB (PDGF-BB), Fibroblast Growth Factors-base (bFGF), and their combinations for SCs in collagen gel(More)
The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and elevated ROS levels in cancer cells, attenuating cell(More)
MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides (nt) in length that bind to the 3′UTRs of their target mRNAs, leading to translational inhibition or mRNA degradation (Bartel, 2009). miRNAs regulate the expression of hundreds of genes involved in various biological processes , such as apoptosis, migration, metastasis, and Previous studies(More)
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