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PGL-1 is a constitutive protein component of C. elegans germ granules, also known as P granules. Maternally supplied PGL-1 is essential for germline development but only at elevated temperature, raising the possibility that redundant factors provide sufficient function at lower temperatures. We have identified two PGL-1-related proteins, PGL-2 and PGL-3, by(More)
PURPOSE The parapapillary gamma zone has been defined as the parapapillary region without Bruch's membrane. We examined which morphologic parameters are associated with the presence and size of the parapapillary gamma zone. METHODS Using fundus photographs and spectral-domain optical coherence tomographic images of the optic nerve head in the(More)
Oral and pharyngeal cancer is the sixth most common cancer worldwide, the 5-year survival rate has not yet increased. A key factor in rates not having improved is the lack of early detection. This study was undertaken to estimate the diagnostic accuracy of brush biopsy with DNA-image cytometry (a noninvasive method) for potentially malignant oral disorders(More)
BACKGROUND To explore the hypothesis that burning mouth syndrome (BMS) probably is a neuropathic pain condition, thermal and mechanical sensory and pain thresholds were tested and compared with age- and gender-matched control participants using a standardized battery of psychophysical techniques. METHODS Twenty-five BMS patients (men: 8, women: 17, age:(More)
Oral lichen planus (OLP) is generally accepted to be a T cell-mediated chronic inflammatory disease with an unclear pathogenesis. There have been numerous studies on the proliferation and apoptosis of T cells in situ. In contrast, research on the proliferation and apoptosis of peripheral blood mononuclear cells (PBMCs) in patients with OLP is rare. The aim(More)
PURPOSE The purpose of this study was to explore the pathogenesis and carcinogenesis of oral leukoplakia (LK) and oral lichen planus (OLP) by examining the expression of apoptosis-associated proteins Bcl-2 Bax in LK and OLP. METHODS The expression of Bcl-2 and Bax were measured in 10 cases of normal oral mucosa,18 cases of OLP, 23 cases of LK and 22 cases(More)
OBJECTIVE To evaluate the effects of Shengli capsules on the sexual ability of normal and castrated male rats. METHODS Shengli capsules were given by intragastric administration to 100 experimental male rats at different doses of 0.35, 0.70 and 1.40 g / kg. Data were collected and analyzed, including capture latency period, times of capture, sexual(More)
It has been well-established that apoptosis contributes to cancer cell death; however, the role of autophagy in cancer cell death remains unclear. The aim of the present study was to investigate the effects of rottlerin, a traditional Indian medicine, on cell growth inhibition and autophagy in EJ human bladder carcinoma cells in vitro. Cell viability,(More)
OBJECTIVE To examine the effect of mouthwash Yupingfeng on the level of salivary epidermal growth factor (sEGF) in oral lichen planus (OLP). METHODS The level of sEGF was measured by radioimmunoassay with ligand 125I-EGF. The saliva samples were taken from the normal control group and the OLP patients before and after treatment with Yupingfeng. RESULTS(More)
Oral lichen planus (OLP) is suggested to be a T cell-mediated chronic inflammatory oral mucosal disease. Gene expressed in the oligodendrocyte lineage-myelin basic proteins (Golli-MBP) and stromal interaction molecule 1 (STIM1) are important in the activation and function of T lymphocytes. This study aimed to analyze and compare the expression of Golli-MBP(More)