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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
TLDR
The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described. Expand
Thrombocytopenia and its association with mortality in patients with COVID‐19
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes novel coronavirus disease 2019 (COVID‐19), is spreading rapidly around the world. Thrombocytopenia in patients with COVID‐19Expand
Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China
TLDR
The duration of the negative conversion of SARS-CoV-2 RNA and its association with the severity of critically ill patients with COVID-19 should be seriously considered and further studied. Expand
Ribavirin therapy for severe COVID-19: a retrospective cohort study
TLDR
Ribavirin was not associated with reduced negative conversion time of SARS-CoV-2 PCR test compared with the control group and did not reduce the mortality rate compared withThe control group. Expand
Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo
TLDR
Data indicate that MaR1 inhibits TGF-&bgr;1-induced EMT and attenuates bleomycin-induced pulmonary fibrosis and may be a promising strategy for alleviation of lung fibrosis. Expand
BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway
TLDR
It is demonstrated that BML-111 can reduce the neuroinflammation and cognitive impairment induced by sepsis via SIRT/NF-κB signaling pathway via intracerebroventricular injection. Expand
Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19
TLDR
Target metabolomic and lipidomic analyses of plasma from a cohort of COVID-19 patients found the metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected whole-body metabolism of the patients. Expand
The changes of leukocyte telomere length and telomerase activity after sitagliptin intervention in newly diagnosed type 2 diabetes
TLDR
The aim of this study was to determine whether sitagliptin, a medicine generally used in diabetes, can influence the telomere and telomerase in newly diagnosed type 2 diabetic patients. Expand
High-mobility group box 1 protein participates in acute lung injury by activating protein kinase R and inducing M1 polarization.
TLDR
Results indicate that HMGB1 participates in the pathogenesis of ALI by activating PKR in macrophages and inducing M1 polarization through TLR2- and TLR4-mediated NF-κB signaling pathways. Expand
Miniaturization of immunoassay by using a novel module-level immunosensor with polyaniline-modified nanoprobes that incorporate impedance sensing and paper-based sampling
This work presents a module-level impedance measurement system integrated with a disposable immunosensor for the immunoassay of bladder cancer cell lysate (T24) to a specific antibody (galectin-1).Expand
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