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Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
TLDR
The findings indicate that there is an association of SNP C677T in the MTHFR gene with male infertility, suggesting that this polymorphism might be a genetic risk factor for male infertility in Chinese men.
Ataxin-2 intermediate-length polyglutamine: a possible risk factor for Chinese patients with amyotrophic lateral sclerosis
TLDR
Evidence that the ATXN2 polyQ expansion greater than 27 might be a risk factor for Chinese SALS patients is provided, found to be weakly associated with amyotrophic lateral sclerosis in this study.
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation.
TLDR
Fenofibrate can induce lipoprotein glomerulopathy remission and the fibrate effects depend on the degree of lipid control and baseline proteinuria, and normalization of serum apoE and triglycerides can be used to judge the efficacy of lipid-lowering treatment.
Chromosomal abnormality and Y chromosome microdeletion in Chinese patients with azoospermia or severe oligozoospermia.
TLDR
Chromosomal abnormality and AZF region microdeletion of Y chromosome might account for about 25% of Chinese infertile patients with azoospermia or severe oligozoospermia, suggesting the two abnormalities are important genetic etiology of spermatogenic failure in Chinese population.
CGCG clinical practice guidelines for the management of adult diffuse gliomas.
TLDR
The recommendations will provide a framework and assurance for the strategy of diagnostic and therapeutic measures to reduce complications from unnecessary treatment and cost and should serve as an application for all professionals involved in the management of patients with adult diffuse glioma and also as a source of knowledge for insurance companies and other institutionsinvolved in the cost regulation of cancer care in China.
Microarray profiling of microRNAs expressed in testis tissues of developing primates
TLDR
PicTar and TargetScan prediction tools predicted a number of target mRNAs, and some of these target genes predicted by miRNAs have been shown to associate with spermatogenesis.
Y chromosome haplogroups may confer susceptibility to partial AZFc deletions and deletion effect on spermatogenesis impairment.
TLDR
The findings indicate that some monophyletic Y chromosomes may be associated with predisposition to specific subtypes of partial AZFc deletion and adverse effect on spermatogenesis in a Chinese population.
Treatment for lupus nephritis: an overview of systematic reviews and meta-analyses
TLDR
For LN induction therapy, both Tacrolimus and MMF are more effective and safer than cyclophosphamide, while there are no differences of efficacy or safety between the two treatments, and for LN maintenance therapy, MMF seems to have less adverse events and lower relapse rate than azathioprine.
SNCA variants rs2736990 and rs356220 as risk factors for Parkinson’s disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population
TLDR
The results show that rs2736990 and rs356220 in SNCA decreased the risk for PD in a Chinese population and these candidate polymorphisms were unlikely to be the causes of SALS and MSA in this population.
Identification of novel mutations in Chinese Hans with autosomal dominant polycystic kidney disease
TLDR
Mutation study of PKD1 and PKD2 genes in Chinese Hans with ADPKD may contribute to a better understanding of the genetic diversity between different ethnic groups and enrich the mutation database.
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