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Presented here is a genome sequence of an individual human. It was produced from approximately 32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled into 4,528 scaffolds, comprising 2,810 million bases (Mb) of contiguous sequence with approximately 7.5-fold coverage for any given region. We developed a modified version of the(More)
OpenMP has been very successful in exploiting structured parallelism in applications. With increasing application complexity, there is a growing need for addressing irregular parallelism in the presence of complicated control structures. This is evident in various efforts by the industry and research communities to provide a solution to this challenging(More)
The physical layer of most wireless protocols is traditionally implemented in custom hardware to satisfy the heavy computational requirements while keeping power consumption to a minimum. These implementations are time consuming to design and difficult to verify. A programmable hardware platform capable of supporting software implementations of the physical(More)
Endosomal sorting complex required for transport III (ESCRT-III) proteins function in multivesicular body biogenesis and viral budding. They are recruited from the cytoplasm to the membrane, where they assemble into large complexes. We used "deep-etch" electron microscopy to examine polymers formed by the ESCRT-III proteins hSnf7-1 (CHMP4A) and hSnf7-2(More)
DNA and RNA oligomers are used in a myriad of diverse biological and biochemical experiments. These oligonucleotides are designed to have unique biophysical, chemical and hybridization properties. We have created an integrated set of bioinformatics tools that predict the properties of native and chemically modified nucleic acids and assist in their design.(More)
Language and image understanding are two major goals of artificial intelligence which can both be conceptually formulated in terms of parsing the input signal into a hierarchical representation. Natural language researchers have made great progress by exploiting the 1D structure of language to design efficient polynomial-time parsing algorithms. By(More)
Aerosol mass spectrometry has proved to be a powerful tool to measure submicron particulate composition with high time resolution. Factor analysis of mass spectra (MS) collected worldwide by aerosol mass spectrometer (AMS) demonstrates that submicron organic aerosol (OA) is usually composed of several major components, such as oxygenated (OOA),(More)
Reducing sugars (RS) accumulation in potato (Solanum tuberosum L.) tubers stored at low temperature, a phenomenon known as cold-induced sweetening, is a serious postharvest problem for the potato processing industry. RS accumulation is prevented by suppression of a gene encoding potato vacuolar acid invertase (StvacINV1), which catalyzes irreversible(More)