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Targeted induction of apoptosis in glioblastoma multiforme cells by an MRP3-specific TRAIL fusion protein in vitro
Single-chain Fv fragments (scFvs) consist of the variable heavy-chain (VH) and variable light-chain (VL) domains, which are the smallest immunoglobulin fragments containing the whole antigen-bindingExpand
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S5a binds to death receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-&kgr;B pathway
ABSTRACT Analyses of supernatants from apoptotic cells have helped in the identification of many signals that modulate the states of cell activation and differentiation. However, the currentExpand
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Dual redox-responsive PEG–PPS–cRGD self-crosslinked nanocapsules for targeted chemotherapy of squamous cell carcinoma
Polymer nanogels/nanocapsules with encapsulation stability, stimuli responsiveness and tumor targeting have emerged as one of the most remarkable carriers for anticancer drug delivery. In this work,Expand
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Effects of JAG1 gene silencing on proliferation and apoptosis of human breast cancer MDA-MB-231 cells
AIM:To investigate the effects of Jagged 1(JAG1) gene silencing on the proliferation and apoptosis of human breast cancer MDA-MB-231 cells.METHODS:The specific recombinant vector pRS-JAG1 wasExpand
pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery
A smart polycarbonate(PCA) copolymer-based nanoparticle(NanoPCA) with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling aExpand
MMP-responsive in situ forming hydrogel loaded with doxorubicin-encapsulated biodegradable micelles for local chemotherapy of oral squamous cell carcinoma
The complex construction within the oral cavity causes incomplete surgical resection of oral squamous cell carcinoma (OSCC) that may enhance the risk of recurrence and metastasis in the treatment. InExpand
MiR-490-5p functions as tumor suppressor in childhood neuroblastoma by targeting MYEOV
Neuroblastoma (NB) is the most common extracranial solid tumor derived from neural crest in children. Recently, the role of miRNA has been studied extensively in the development of NB. Here, weExpand