Yuan Jie Yang

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The C-terminal V5 domain is one of the most variable domains in Protein Kinase C isoforms (PKCs). V5 confers isoform specificity on its parent enzyme through interactions with isoform-specific adaptor proteins and possibly through specific intra-molecular interactions with other PKC domains. The structural information about V5 domains in solution is sparse.(More)
Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions worldwide for its anti-tumor efficacy. Celastrol and Triptolide, two active components extracted from the Chinese herb Tripterygium wilfordii Hook F (known as Lei Gong Teng or Thunder of God Vine), have shown anti-tumor effects. Celastrol was identified as a natural 26(More)
Research on reach-to-grasp movements generally concentrates on kinematics values that are expression of maxima, in particular the maximum aperture of the hand and the peak of wrist velocity. These parameters provide a snapshot description of movement kinematics at a specific time point during reach, i.e., the maximum within a set of value, but do not allow(More)
Polarized membrane morphogenesis is a fundamental activity of eukaryotic cells. This process is essential for the biology of cells and tissues, and its execution demands exquisite temporal coordination of functionally diverse membrane signaling reactions with high spatial resolution. Moreover, mechanisms must exist to establish and preserve such(More)
BACKGROUND Several studies have demonstrated that uremic patients who have preserved left ventricular ejection fraction (LVEF) could still have the potential for systolic dysfunction. The aim of this study was to assess the differences between the left ventricular (LV) myocardial function in hemodialysis and nondialysis uremic patients based on(More)
The Ningxia Hui Autonomous Region (NX region) of Northwestern China is threatened by increased meteorological drought induced by climate change (CC) and constraints on water supply from the Yellow River. Thus, the NX region is representative of attempts to adapt to CC and variability in China's arid regions. Field visits, a questionnaire and in situ(More)
While much has been written about how consumers make decisions to purchase foreign brand-name products, relatively less is known about the effect of international relations on the market performance of the products of one country in another with which it has conflicts. Motivated by this gap in the literature, we test the effect of the relationship between(More)
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