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A Highly Efficient Approach To Construct (epi)-Podophyllotoxin-4-O-glycosidic Linkages as well as Its Application in Concise Syntheses of Etoposide and Teniposide.
TLDR
A highly efficient approach to construct the challenging (epi)-podophyllotoxin 4-O-glycosidic linkages was devised under the activation of a catalytic amount of a Au(I) complex, providing the desired glycosides in excellent yields. Expand
Highly efficient synthesis of flavonol 5-O-glycosides with glycosyl ortho-alkynylbenzoates as donors.
With glycosyl ortho-alkynylbenzoates as donors, the highly efficient glycosylation of flavonoid 5-OH which are notorious for their low reactivity due to their involvement in the formation of strongExpand
Synthetic Access Toward Cycloastragenol Glycosides.
TLDR
Through the synthetic investigation, the reactivity sequence of the four OHs in cycloastragenol was fixed for the first time and a detour strategy for the highly efficient removal of bulky pivaloyl protecting groups was discovered. Expand
Synthetic investigation toward apigenin 5-O-glycoside camellianin B as well as the chemical structure revision.
TLDR
The first total synthesis of the proposed structure of apigenin-5-O-glycoside camellianin B was achieved, wherein three approaches, one linear and two convergent, were established, through which the synthetic structures were firmly corroborated. Expand
Diversity-Oriented Synthesis of Steviol Glycosides.
TLDR
A facile, diversity-oriented, and economic protocol for the synthesis of structurally defined steviol glycosides was established and these high-intensity sweeteners and potential lead compounds for drug development are now readily accessible. Expand
The Catalytically Lignan-Activation-Based Approach for the Synthesis of (epi)-Podophyllotoxin Derivatives.
TLDR
The first catalytic and lignan-activation-based approach for (epi)-podophyllotoxin derivatization was established, featuring an in situ anomerization of the hemiacetal OHs in the critical condensation step. Expand
Synthetic Investigation toward the D‐Ring‐Functionalized Cytotoxic Oleanane‐Type Saponins Pithedulosides D and E
Leveraging on the orchestrated application of both Schmidt and Yu glycosylations, the first total syntheses of echinocystic acid saponins, pitheduloside D and E, the two antitumoral andExpand
Palladium-Catalyzed Cross-Coupling of 2-Iodoglycals with N-Tosylhydrazones: Access to 2-C-Branched Glycoconjugates and Oxadecalins.
A convenient and straightforward synthesis of diverse 2-C-alkenyl-glycosides through a palladium-catalyzed cross-coupling reaction between 2-iodoglycals and N-tosylhydrazones has been developed.Expand
Cu-Catalyzed/mediated synthesis of N-fluoroalkylanilines from arylboronic acids: fluorine effect on the reactivity of fluoroalkylamines.
An oxidative coupling reaction of fluoroalkylamines with arylboronic acids has been achieved for the first time. Fluorine has profound influence on the reactivity and fluoroalkylated amines have theExpand
Reagent-Controlled Divergent Synthesis of C-Glycosides.
TLDR
A reagent-controlled protocol for divergent and regio- and stereo-selective synthesis of C-glycosides has been established and the silence of the directing effect of o-DPPB was achieved by the introduction of ZnCl2 additive, which is operationally simple and efficient. Expand
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