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A conserved molecular cascade involving Nodal signaling that patterns the laterality of the lateral mesoderm in vertebrates has been extensively studied, but processes involved in the initial break of left-right (LR) symmetry are just beginning to be explored. Here we report that Na,K-ATPase alpha2 and Ncx4a function upstream of Nodal signaling to regulate(More)
Cardiac fibrillation, a form of cardiac arrhythmia, is the most common cause of embolic stroke and death associated with heart failure. The molecular mechanisms underlying cardiac fibrillation are largely unknown. Here we report a zebrafish model for cardiac fibrillation. The hearts of zebrafish tremblor (tre) mutants exhibit chaotic movements and fail to(More)
Chinese word segmentation (CWS), named entity recognition (NER) and part-of-speech tagging is the lexical processing in Chinese language. This paper describes the work on these tasks done by France Tele-com Team (Beijing) at the fourth International Chinese Language Processing Bake-off. In particular, we employ Conditional Random Fields with different(More)
Blockade of transforming growth factor-β (TGF-β) signaling by Smad7 gene therapy is known to prevent experimental renal fibrosis. This study investigated whether Smad7 suppresses renal fibrosis via altering the renal expression of fibrosis-related microRNAs. Application of gene therapy into diseased kidneys of obstructive nephropathy and kidney cells by(More)
Mitochondria play a central role in the regulation of programmed cell death signaling. Here, we report the finding of a mitochondrial matrix-targeted protein phosphatase 2C family member (PP2Cm) that regulates mitochondrial membrane permeability transition pore (MPTP) opening and is essential for cell survival, embryonic development, and cardiac function.(More)
Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. A search for alternative antidiabetic drugs from herbs or fungi is highly demanded. Our present study aims to investigate the antidiabetic activities of Cordyceps militaris on diet-streptozotocin-induced type 2 diabetes mellitus in rats.(More)
Joint factor analysis (JFA) has been successfully applied to speaker verification tasks to tackle speaker and session variability. In the sense of Bayesian statistics, it is beneficial to take account of the uncertainties in JFA to better characterize its speaker enrollment and verification processes, e.g. representing target speaker model by posteriori(More)
The negative effect of the session variability has become more and more severe for the performance of the speaker verification system. This paper discusses the eigenchannel compensation and investigates the symmetric scoring method to diminish the session variability and further enhance the performance. Experiments were conducted on the core tests of the(More)
PURPOSES To investigate the frequencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China. Moreover, to compare the prevalence of these abnormalities with other countries and regions in the world. METHODS 305 infertile men were enrolled. A complete semen analysis and reproductive hormones were measured according(More)
We have previously shown that transforming growth factor-β/Smad3-dependent miRNAs play a critical role in renal inflammation and fibrosis. However, off-target effects of miRNAs limit their therapeutic application. Recently, emerging roles of long noncoding RNAs (lncRNAs) in diseases have been recognized. In this study, we used high-throughput RNA sequencing(More)