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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a myocardial disease characterized by fibro-fatty replacement of myocardium in the right ventricular free wall and frequently results in life-threatening ventricular arrhythmias and sudden cardiac death. A heterozygous missense mutation in the transmembrane protein 43 (TMEM43) gene, p.S358L, has been(More)
Analyzing topological properties of drug-target proteins in the biology network is very helpful in understanding the mechanism of drug action. However, comprehensive studies to elaborately characterize the biological network features of drug-target proteins are still lacking. In this paper, we compared the topological properties of drug-targets with those(More)
Web service technologies are becoming increasingly important for integrating service-oriented applications. The Web services reverse engineering process becomes necessary in order to facilitate the reuse and composition of Web services. This paper describes a model driven Web service reverse engineering process, where Web service descriptions (WSDL) are(More)
Requirements evolve continuously and inevitably. In order to effectively manage requirements change, an understanding from a quantitative perspective is needed in determining the extent of the propagation of the requirements as they evolve. In this paper, we first look back at the impact analysis in the software life cycle and give an overview of(More)
Power wheelchairs have been widely used to provide independent mobility to people with disabilities. Despite great advancements in power wheelchair technology, research shows that wheelchair related accidents occur frequently. To ensure safe maneuverability, capturing wheelchair maneuvering patterns is fundamental to enable other research, such as safe(More)
The purpose of this pilot study was to provide a new approach for capturing and analyzing wheelchair maneuvering data, which are critical for evaluating wheelchair users' activity levels. We proposed a mobile-cloud (MC) system, which incorporated the emerging mobile and cloud computing technologies. The MC system employed smartphone sensors to collect(More)
Functional modules are basic units of cell function, and exploring them is important for understanding the organization, regulation and execution of cell processes. Functional modules in single biological networks (e.g., the protein-protein interaction network), have been the focus of recent studies. Functional modules in the integrated network are(More)
Viral genes may act as oncogenes and interact with intracellular proteins, which are related to oncogenesis and tumor growth. Autocrining CXCL12 in growing tumor tissue plays critical roles in modulating cell proliferation and survival through its receptor CXCR4 and CXCR7. Recently, a number of research reports indicated that CXCR7 displays high expression(More)
Autotrophic bacteria are able to catalyze cathodic oxygen reduction as a renewable and sustainable inexpensive catalyst. However, the performance of biocathode varied over reactors, and we still not know how inoculums affect this system. Using three different inoculum of wastewater (WW), sediment extract (SE) and soil extract (SO) in parallel reactors, we(More)
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