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Des-γ-Carboxy Prothrombin (DCP) as a Potential Autologous Growth Factor for the Development of Hepatocellular Carcinoma
TLDR
Recent studies on DCP in biological roles related to cancer progression and angiogenesis in HCC are summarized and its biological malignant potential is specified.
Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice
TLDR
Naringin by oral administration prevented AOM/DSS-induced ulcerative colitis and carcinogenesis without significant side effects and could develop a promising therapeutic agent for the prevention of ulceration and colorectal tumor.
Naringin, a natural dietary compound, prevents intestinal tumorigenesis in ApcMin/+ mouse model
TLDR
Naringin prevented intestinal tumorigenesis likely through a collection of activities including anti-proliferation, induction of apoptosis, modulation of GSK-3β and APC/β-catenin pathways and anti-inflammation.
A112, a tamibarotene dimethylaminoethyl ester, may inhibit human leukemia cell growth more potently than tamibarotene
TLDR
It is suggested that A112 is a highly effective derivative of trans retinoic acid and a potential candidate compound for the treatment of leukemia.
Des-Gamma-Carboxy Prothrombin (DCP) Antagonizes the Effects of Gefitinib on Human Hepatocellular Carcinoma Cells
TLDR
DCP antagonized gefitinib-induced HCC cell growth inhibition by counteracting apoptosis and up-regulating the EGFR pathway and might thus lead to low response rates or possibly no response to gefithinib in patients with HCC.
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