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INTRODUCTION The natural product tetramethylpyrazine (TMP) has a variety of biologic activities, including neuroprotection. Nitrones are powerful free radical scavengers. We have designed and synthesized a TMP derivative, TN-2, which is armed with two nitrone moieties. AIMS In this study, we investigated the neuroprotective effect of TN-2 against(More)
Infections with influenza A viruses are still a major threat to humans and several animal species. The occurrence of highly pathogenic avian influenza viruses capable of infecting and killing humans highlights the urgency for a new and efficient strategy for the treatment of diseases caused by the virus. Andrographolide and its derivatives have been widely(More)
BACKGROUND Sunitinib is an inhibitor of the multiple receptor tyrosine kinases (RTKs) for cancer therapy. Some sunitinib analogues could prevent neuronal death induced by various neurotoxins. However, the neuroprotective effects of sunitinib have not been reported. METHODS Cerebellar granule neurons (CGNs) and SH-SY5Y cells were exposed to low-potassium(More)
A sensitive and simple high-performance liquid chromatographic method with UV detection was developed and validated for the determination of andrographolide in rat whole blood. Carbamazepine was employed as internal standard and the blood sample was extracted with chloroform. Chromatographic separations were achieved on a Chromasil ODS column (250 x 4.6 mm,(More)
Neurodegenerative disorders are one of the leading causes of death among the elderly. Therapeutic approaches with a single target have proven unsuccessful in treating these diseases. Structural combination of multi-functional compounds may lead to a molecule with multiple properties. In this study, we designed and synthesized T-006, a novel analog derived(More)
OBJECTIVE To investigate the pharmacokinetics behaviour of tetramethylpyrazine (TMP) by intravenous administration in rats. METHODS Methanol-0.05 mol/L acetate buffer solution (50:50,V/V) was used as mobile phase with a flow rate of 1.0 mL/min. The UV detection wavelength was 280 nm. RESULTS The profile of TMP in blood fitted a two-compartment model.(More)
Athetis lepigone (Möschler) (Lepidoptera: Noctuidae) is an important insect pest of corn crops in China. To determine the effect of temperature on A. lepigone growth, and to provide a forecasting model for this pest, the development and fecundity of A. lepigone under five different temperatures (18, 21, 24, 27, 30 °C) was investigated, and an experimental(More)
OBJECTIVE To investigate the inhibitory effect of TBN on rabbit platelet aggregation in vitro and in vivo, and compare with tetramethylpyrazine (TMP). METHODS To seek out the maximum of platelet aggregation (expressed in percentage) within 5 minutes which was induced by ADP, PAF and AA according to the Born turbidimetric method with a(More)
OBJECTIVE To research and evaluate the clinical efficacy of Xian-zhong injection in treating primary knee OA. METHODS By using Lequesne instituted ISOA and Kellgren-Lawrance instituted X-ray class standard, 127 non-operation primaary knee OA patients were divided into three grades (Light, Moderate, Severe). To adopt randomized single controlled trial,(More)
OBJECTIVE To investigate the effect of Xianzhong Injection (XI) on morphology of knee and insulin-like growth factor-1 (IGF-1) in rabbits with early stage osteoarthritis (OA). METHODS One hundred and twenty rabbits were randomly divided into 5 groups, the blank group, the model group treated with 0.5 mL normal saline once a week, the positive control(More)