Yu-long Zhao

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A novel and efficient route to 4-halogenated N-substituted 2(1H)-pyridinones has been developed via a one-pot domino process of readily available alpha-acetyl-alpha-carbamoyl ketene dithioacetals with Vilsmeier reagents. These 4-halogenated-2(1H)-pyridinones constitute useful intermediates due to the easy elaboration on either the pyridinone core (by the(More)
An efficient synthetic method for 4-functionalized quinoline derivatives, 4-((1,3-dithian-2-ylidene)methyl)quinolines, has been developed. Mediated by trifluoromethanesulfonic acid, ethynyl ketene-S,S-acetals can react in a one-pot procedure with various arylamines and aldehydes under mild conditions to give the corresponding quinoline derivatives in good(More)
We report here that polysubstituted dihydroisoquinolones and isoquinolones can be constructed by the one-pot reaction of the readily available acyclic α,β-unsaturated carbonyl precursors and dialkyl glutaconates under mild basic conditions (1-45 min for the former vs. 1-6 h for the latter) via the domino process involving [3+3] annulation/intramolecular(More)
Diagnosing and quantifying plant-parasitic nematodes is critical for efficient nematode management. Several studies have been performed intending to demonstrate nematode quantification via real-time quantitative PCR. However, most of the studies used dilution of DNA templates to make standard curves, while few studies used samples with different nematode(More)
The transition-metal-catalyzed cross-coupling of phenol derivatives has emerged as an extremely attractive method in synthetic chemistry, because of the many advantages pertaining to the use of phenol derivatives. So far, aryl triflates or nonaflates have frequently been investigated, but their high cost and instability are deterrents to their extensive(More)
Fluorescence-marked lipid binding experiment shows that CaMBP-10 has typical lipid binding feature of non-specific lipid transfer protein (nsLTP). We have compared the effects of calmodulin (CaM) on the lipid-binding activity of CaMBP-10 and maize nsLTP. Different influences were found in the presence of either Ca(2+) or EGTA. W-7 and TFP could abolish the(More)
The one-pot synthesis, crystal structure, and electronic absorption properties of expanded 1,3-dithiolan[5]radialene (6a), the first heteroatom-substituted expanded radialene molecule with dithiolanylidene groups as strongly donor termini, has been developed. Catalyzed by Ni(PPh3)2Cl2-PdCl2-CuI, radialene 6a was assembled by a highly efficient one-pot and(More)
A base-mediated aerobic oxidation of the C-H bond adjacent to the N-atom of a secondary amine to form an imine intermediate under mild metal-free basic conditions has been developed. Accordingly, this new strategy has been successfully applied to the synthesis of various di-, tri-, and tetra-substituted α-aminocyclopentenones through a tandem aerobic(More)
A novel DBU-mediated oxidative cyanation of α-amino carbonyl compounds by using air as the sole oxidant was developed under mild metal-free conditions for the first time. The reaction involves a tandem oxidation/Strecker reaction/oxidation process and provides a new and efficient method for the construction of α-iminonitriles in good to high yields in a(More)
For the first time α-diazocarbonyls have been used as highly active N-terminal electrophiles in the presence of bicyclic amidine catalysts. The CN bond-forming reactions of active methylene compounds as C nucleophiles with α-diazocarbonyls as N-terminal electrophiles proceed quickly under ambient conditions, in the presence of(More)