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LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor
  • Xin-Jiang Lu, J. Chen, +7 authors L. Xu
  • Medicine
  • The Journal of experimental medicine
  • 14 January 2013
Leukocyte cell–derived chemotaxin 2 enhances phagocytosis and bacterial killing of macrophages to improve the outcome of bacterial-induced sepsis.
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Molecular characterization of an IL-1β gene from ayu, Plecoglossus altivelis.
IL-1β plays a crucial role as a prototypical proinflammatory cytokine in immune responses and has been shown to affect macrophage functions. However, the effects of putative IL-1β homologs on fishExpand
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Characterization of P2X7R and Its Function in the Macrophages of ayu, Plecoglossus altivelis
P2X purinoceptor 7 (P2X7R), an ATP-gated ion channel, plays an important role during the innate immune response in mammals. However, relatively little is known about the role of P2X7R in the fishExpand
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Sequencing of the first ayu (Plecoglossus altivelis) macrophage transcriptome and microarray development for investigation the effect of LECT2 on macrophages.
Macrophages play an important role in first-line host defense of innate immune in fishes. However, it is difficult to investigate cellular mechanism of immune response in fish species with littleExpand
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Molecular characterization of an IL-1β gene from the large yellow croaker (Larimichthys crocea) and its effect on fish defense against Vibrio alginolyticus infection.
Interleukin 1β (IL-1β), the first interleukin to be characterized, plays a key role in regulating the immune response. In this study, we determined the cDNA and genomic DNA sequences of the IL-1βExpand
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Molecular characterization of a transmembrane C-type lectin receptor gene from ayu (Plecoglossus altivelis) and its effect on the recognition of different bacteria by monocytes/macrophages.
C-type lectin receptors (CTLRs) play vital roles in immune responses as pattern-recognition receptors (PRRs). In this study, we identified a novel C-type lectin receptor (PaCTLRC) gene from ayu,Expand
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Ayu C‐reactive protein/serum amyloid P agglutinates bacteria and inhibits complement‐mediated opsonophagocytosis by monocytes/macrophages
&NA; The short‐chain pentraxins (PTXs), including C‐reactive protein (CRP) and serum amyloid P (SAP), are soluble pattern recognition molecules (PRMs) that exhibit calcium‐dependent binding toExpand
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[Molecular cloning, sequence analysis and expression pattern of hepcidin gene in ayu (Plecoglossus altivelis)].
Hepcidin, a member of cysteine-rich antimicrobial peptides, plays an important role in both fish adaptive immunity and the regulation of iron metabolism. In this paper, the nucleotide sequence of aExpand
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Detection of bacterial pathogens in aquaculture samples by DNA microarray analysis
Abstract Rapid, sensitive, and specific detection of pathogens is important for effective disease control in aquaculture. However, the use of conventional microbiological methods for pathogenExpand
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Influence of acute cadmium exposure on the liver proteome of a teleost fish, ayu (Plecoglossus altivelis)
Cadmium (Cd) is a toxic heavy metal that causes the disruption of a variety of physiological processes. In this study, the effect of Cd on liver proteome of ayu, Plecoglossus altivelis, wasExpand
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