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Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland
TLDR
Results showed that the subjects carrying the T allele of rs863108 and rs28499371 exhibited a decreased risk for sPD, and the alteration of these SNPs might play some roles through changing/affecting LINC01524/LOC105372666, DMRT2/SMARCA2, PLEKHN1, and FLJ23172/FNDC3B genes in the pathogenesis of sPD.
All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice
TLDR
These findings are the first to indicate that the damaged retinoic acid signal is involved in the pathogenesis of ALS, and ATRA could induce the functional neuroprotection via repairing the damaged Retinoic Acid signal.
Association between inflammatory bowel diseases and Parkinson's disease: systematic review and meta-analysis
TLDR
A meta-analysis indicates a certain correlation between IBD and PD, and suggests that IBD may moderately increase PD risk regardless of sex, especially in patients over 65 years of age, and an urgent need for an individualized screening strategy for patients with IBD.
Altered Features of Vimentin-containing Cells in Cerebrum of Tg(SOD1*G93A)1Gur Mice: A Preliminary Study on Cerebrum Endogenous Neural Precursor Cells in Amyotrophic Lateral Sclerosis
TLDR
In ALS-like Tg(SOD1*G93A)1Gur mice, VCCs in the motor cortex, the olfactory cortex and the cingulate cortex showed that no any proliferation and redistribution in neural cells of VCCS in the cerebrum occurred in all stages of ALS, might migrate to damaged regions.
Aberrant Levels of Cystatin C in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta Analysis
TLDR
Cys C levels significantly decrease in the CSF of ALS patients, but are not a specific biomarker for this disease, while the correlation meta analysis presented no significant correlation between Cys C Levels in CSF and age or disease duration respectively.
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease
TLDR
It is suggested that the extensive alteration of cortical structural connectivity is one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD.
HnRNP G Reduces Neuron Death in Amyotrophic Lateral Sclerosis by Preventing Abnormal TDP-43 Accumulation
TLDR
The distribution of hnRNP G in the spinal cord of ALS mice showed the possible protective effect on the progression of ALS, and its mechanism maybe prevent neuron death through reducing abnormal TDP-43 accumulation in the spine of ALS-like mice.
Potential Common Genetic Risks of Sporadic Parkinson’s Disease and Amyotrophic Lateral Sclerosis in the Han Population of Mainland China
TLDR
Findings provide insight into the molecular pathogenesis of both diseases and can serve as a basis for the development of targeted therapies.