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Current Statistical Machine Translation (SMT) systems translate one sentence at a time, ignoring any document level information. Consequently, translation models are learned only at sentence level and document contexts are generally overlooked. In this paper, we try to introduce document topic to help SMT system to produce target sentences. First, the(More)
Future many-core processors will require high-performance yet energy-efficient on-chip networks to provide a communication substrate for the increasing number of cores. Recent advances in silicon nanophotonics create new opportunities for on-chip networks. To efficiently exploit the benefits of nanophotonics, we propose Firefly - a hybrid, hierarchical(More)
Epistatic interactions among multiple genetic variants in the human genome may be important in determining individual susceptibility to common diseases. Although some existing computational methods for identifying genetic interactions have been effective for small-scale studies, we here propose a method, denoted 'bayesian epistasis association mapping'(More)
Age Specific Human-Computer Interaction (ASHCI) has vast potential applications in daily life. However, automatic age estimation technique is still underdeveloped. One of the main reasons is that the aging effects on human faces present several unique characteristics which make age estimation a challenging task that requires non-standard classification(More)
Location-based services, such as finding the nearest gas station, require users to supply their location information. However, a user’s location can be tracked without her consent or knowledge. Lowering the spatial and temporal resolution of location data sent to the server has been proposed as a solution. Although this technique is effective in protecting(More)
Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we(More)
Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex. Transcriptional target analysis revealed that the LSD1/NuRD complexes regulate several cellular(More)
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear. For a largely unknown regulatory mechanism, a rate-limiting glycolytic enzyme pyruvate kinase M2 (PKM2) isoform is exclusively expressed in embryonic, proliferating, and tumor cells,(More)
Rice is the principal food for over half of the population of the world. With its genome size of 430 megabase pairs (Mb), the cultivated rice species Oryza sativa is a model plant for genome research. Here we report the sequence analysis of chromosome 4 of O. sativa, one of the first two rice chromosomes to be sequenced completely. The finished sequence(More)
RNA structure has critical roles in processes ranging from ligand sensing to the regulation of translation, polyadenylation and splicing. However, a lack of genome-wide in vivo RNA structural data has limited our understanding of how RNA structure regulates gene expression in living cells. Here we present a high-throughput, genome-wide in vivo RNA structure(More)