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Future many-core processors will require high-performance yet energy-efficient on-chip networks to provide a communication substrate for the increasing number of cores. Recent advances in silicon nanophotonics create new opportunities for on-chip networks. To efficiently exploit the benefits of nanophotonics, we propose Firefly - a hybrid, hierarchical(More)
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine. Typically, hESC-based applications would require their in vitro differentiation into a desirable homogenous cell population. A major challenge of the current hESC differentiation paradigm is the inability to effectively capture and, in the long-term, stably expand primitive(More)
Seasonal changes in day length are perceived by plant photoreceptors and transmitted to the circadian clock to modulate developmental responses such as flowering time. Blue-light-sensing cryptochromes, the E3 ubiquitin-ligase COP1, and clock-associated proteins ELF3 and GI regulate this process, although the regulatory link between them is unclear. Here we(More)
The plant vacuole is an important organelle for storing excess iron (Fe), though its contribution to increasing the Fe content in staple foods remains largely unexplored. In this study we report the isolation and functional characterization of two rice genes OsVIT1 and OsVIT2, orthologs of the Arabidopsis VIT1. Transient expression of OsVIT1:EGFP and(More)
Age Specific Human-Computer Interaction (ASHCI) has vast potential applications in daily life. However, automatic age estimation technique is still underdeveloped. One of the main reasons is that the aging effects on human faces present several unique characteristics which make age estimation a challenging task that requires non-standard classification(More)
Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types which are involved in a great variety of cellular processes. Reversible acetylation on the epsilon-amino group of alpha-tubulin Lys40 marks stabilized microtubule structures and may contribute to regulating microtubule dynamics. Yet, the enzymes catalysing this(More)
To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells (iPSCs), we investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells. Our analysis suggested that newborn cord blood (CB) and adult peripheral blood (PB) mononuclear cells (MNCs)(More)
Location-based services, such as finding the nearest gas station , require users to supply their location information. However, a user's location can be tracked without her consent or knowledge. Lowering the spatial and temporal resolution of location data sent to the server has been proposed as a solution. Although this technique is effective in protecting(More)
An essential part of the cellular response to environmental stress is a reversible translational suppression, taking place in dynamic cytoplasmic structures called stress granules (SGs). We discovered that HDAC6, a cytoplasmic deacetylase that acts on tubulin and HSP90 and also binds ubiquitinated proteins with high affinity, is a novel critical SG(More)