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Total Synthesis of Actinophyllic Acid.
A total synthesis of the indolohydroazocine natural product actinophyllic acid is reported, featuring chemoselective catalytic dihydroxylation, desymmetrizing nitrile oxide dipolar cycloaddition, and palladium-catalyzed aminoarylation to sequentially modify the three olefins within the trienone, followed by a late-stage reductive cascade indolization and alkylation.
Synthetic studies toward penitrem E: enantiocontrolled construction of B-E rings.
- Yu Yoshii, Takanori Otsu, Norihiko Hosokawa, K. Takasu, K. Okano, H. Tokuyama
- ChemistryChemical communications
- 21 January 2015
Diastereoselective Tf2NH-catalyzed (2+2)-cycloaddition between silyl enol ether and methyl acrylate furnished a tetracyclic product possessing the characteristic cyclobutane ring bearing a hydroxyl group.
SYNTHETIC STUDIES ON PASPALINE : LEWIS ACID-MEDIATED SEQUENTIAL CONSTRUCTION OF A-E RING SKELETON (Dedicated to Dr. Albert Padwa on his 75th birthday)
Synthetic Studies on Paspaline: Lewis Acid‐Mediated Sequential Construction of A‐E Ring Skeleton.
The pentacyclic indole skeleton of diterpene alkaloids of the paspaline family is constructed starting via 1,2-addition of 2-lithioindole to enone compound (IV) followed by a one-pot sequential…