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IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium
Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFTExpand
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Proteins that control the geometry of microtubules at the ends of cilia
Cilia, essential motile and sensory organelles, have several compartments: the basal body, transition zone, and the middle and distal axoneme segments. The distal segment accommodates key functions,Expand
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Kinesin-13 regulates the quantity and quality of tubulin inside cilia
Kinesin-13, a microtubule-end depolymerase, has been shown to affect the length of cilia, but its ciliary function is unclear. In Tetrahymena thermophila, kinesin-13 positively regulates the axonemeExpand
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LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena
The length of cilia is controlled by a poorly understood mechanism that involves members of the conserved RCK kinase group, and among them, the LF4/MOK kinases. The multiciliated protist model,Expand
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LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena
The length of cilia is controlled by a poorly understood mechanism that involves members of the conserved RCK kinase group, and among them, the LF4/MOK kinases. In Tetrahymena, a loss of an LF4/MOKExpand
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Total internal reflection fluorescence microscopy of intraflagellar transport in Tetrahymena thermophila.
Live imaging has become a powerful tool in studies of ciliary proteins. Tetrahymena thermophila is an established ciliated model with well-developed genetic and biochemical approaches, but its largeExpand
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The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena
The mechanisms governing organelle pattern formation in ciliates are still poorly understood. Jiang et al. investigate how the cell duplicates its.... The mechanisms that govern pattern formationExpand
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Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate Tetrahymena
Ciliates divide by tandem duplication, a developmental process that remodels the parental cell into two daughters aligned head-to-tail. Here, Jiang et al. investigate the elo1-1 mutation inExpand
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Kinesin‐14 is Important for Chromosome Segregation During Mitosis and Meiosis in the Ciliate Tetrahymena thermophila
Ciliates such as Tetrahymena thermophila have two distinct nuclei within one cell: the micronucleus that undergoes mitosis and meiosis and the macronucleus that undergoes amitosis, a type of nuclearExpand
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Mutual antagonism between Hippo signaling and cyclin E drives intracellular pattern formation.
Not much is known about how organelles organize into patterns. In ciliates, the cortical pattern is propagated during "tandem duplication," a cell division that remodels the parental cell into twoExpand