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AIM To study the effect of wild type (wt) p53 gene transfection on drug resistant human hepatocellular carcinoma (HCC) cells induced by 5-Fluorouracil (5-FU). METHODS The cytotoxicity of anticancer drugs on Bel7402 and Bel7402/5-FU cells was assessed using SRB assay. p53 expression was detected at its mRNA level by RT-PCR assay and at its protein level(More)
OBJECTIVE To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. METHODS Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair(More)
Mitochondrial diabetes is a kind of rare diabetes caused by monogenic mutation in mitochondia. The study aimed to summarize the clinical phenotype profiles in mitochondrial diabetes withm.3243A>G mitochondrial DNA mutation and to investigate the mechanism in this kind of diabetes by analyzing the relationship among clinical phenotypes and peripheral(More)
OBJECTIVE To investigate the expression of phosphatase and tension homolog (PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes. METHODS KKAy diabetic mice were fed with high fat diet for 4 weeks. After blood glucose met the criteria of diabetes (over 16.7 mmol/L), mice were randomly divided into 3 groups: a control group(More)
BACKGROUND This prospective, randomized, controlled study was designed to investigate the effects of a diabetes specific formula (Diason low energy: 313.8 kJ/100 ml), compared with a standard formula, on insulin sensitivity, serum C peptide, serum lipids and free fatty acid (FFA) in type 2 diabetics. METHODS In total of 71 type 2 diabetics completed the(More)
OBJECTIVE To evaluate the effect of the needle free injection system (INJEX30) and insulin pen on insulin absorption and glycemic control in diabetic patients. METHODS A total of 30 diabetic patients on insulin therapy without obvious complications were enrolled in the study with average BMI of 25.24 kg/m(2). A comparison study was carried out in those(More)
OBJECTIVE To improve the diagnostic accuracy of lung cancer with metastasis to pituitary gland. METHODS The clinical data of 6 cases with lung cancer metastatic to pituitary gland were reviewed retrospectively and the features of clinical manifestations and sella MRI image analyzed. RESULTS (1) The patients had an average of 57.5 years of age. (2) Most(More)
The treatment of type 2 diabetes mellitus (T2DM) is traditionally focused on glycemic control. In recent years, comprehensive treatment approaches including blood sugar control, blood pressure management, and use of antihyperlipidemic agents (e.g. statins) and aspirin play critical roles in improving the outcomes of T2DM. Some newly developed approaches(More)