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The Kv4 A-type potassium currents contribute to controlling the frequency of slow repetitive firing and back-propagation of action potentials in neurons and shape the action potential in heart. Kv4 currents exhibit rapid activation and inactivation and are specifically modulated by K-channel interacting proteins (KChIPs). Here we report the discovery and(More)
As the counterfactual model of causality has increased in popularity, sociologists have returned to matching as a research methodology. In this article, advances over the past two decades in matching estimators are explained, and the practical limitations of matching techniques are emphasized. The authors introduce matching methods by focusing first on(More)
Past research has reported that Asian-Americans, and Asian immigrants in particular, have lower earnings than do whites within the same levels of education. However, few studies have explored why this earnings disadvantage exists. This article investigates whether and to what extent this disadvantage can be attributed to the lower value of foreign education(More)
China's rural-to-urban migration has affected 12.6 million school-age rural children who have migrated with their parents and another 22 million who have been left behind by their migrant parents. Not enough is known, either theoretically or empirically, about the causal impact of migration on the well-being of this large number of Chinese children affected(More)
  • Haoxing Xu, I Scott Ramsey, Suhas A Kotecha, Magdalene M Moran, Jayhong A Chong, Deborah Lawson +7 others
  • 2002
Transient receptor potential (TRP) proteins are cation-selective channels that function in processes as diverse as sensation and vasoregulation. Mammalian TRP channels that are gated by heat and capsaicin (>43 degrees C; TRPV1 (ref. 1)), noxious heat (>52 degrees C; TRPV2 (ref. 2)), and cooling (< 22 degrees C; TRPM8 (refs 3, 4)) have been cloned; however,(More)
Under pressure, metals exhibit increasingly shorter interatomic distances. Intuitively, this response is expected to be accompanied by an increase in the widths of the valence and conduction bands and hence a more pronounced free-electron-like behaviour. But at the densities that can now be achieved experimentally, compression can be so substantial that(More)
The study of ion channel-mediated changes in membrane potential using the conventional bisoxonol fluorescent dye DiBAC(4)(3) has several limitations, including a slow onset of response and multistep preparation, that limit both the fidelity of the results and the throughput of membrane potential assays. Here, we report the characterization of the FLIPR(More)
An important class of scientific and engineering workflows, e.g. those used for uncertainty quantification, design optimization and parametric studies, naturally map onto the Many-Task Computing (MTC) paradigm. However, what distinguishes these workloads is a unique combination of dynamically changing resource requirements and very large computational and(More)