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Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not orally bioavailable, which would limit(More)
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises proapoptotic and prosurvival proteins, and shifting the balance toward the latter is an established mechanism whereby cancer cells evade apoptosis. The therapeutic potential of directly inhibiting prosurvival proteins was unveiled with the(More)
In this study, two WRKY genes were isolated from Erysiphe necator-resistant Chinese wild Vitis pseudoreticulata W. T. Wang ‘Baihe-35-1’, and designated as VpWRKY1 (GenBank accession no. GQ884198) and VpWRKY2 (GenBank accession no. GU565706). Nuclear localization of the two proteins was demonstrated in onion epidermal cells, while trans-activation function(More)
In this paper, we study the restoration of images corrupted by Gaussian plus impulse noise, and propose a l1–l0 minimization approach where the l1 term is used for impulse denoising and the l0 term is used for a sparse representation over certain unknown dictionary of images patches. The main algorithm contains three phases. The first phase is to identify(More)
High-data-rate sensors, such as video cameras, are becoming ubiquitous in the Internet of Things. This article describes GigaSight, an Internet-scale repository of crowd-sourced video content, with strong enforcement of privacy preferences and access controls. The GigaSight architecture is a federated system of VM-based cloudlets that perform video(More)
Previous studies have shown that a significant part of the overall energy consumption of battery-powered mobile devices is caused by network data transmission. Power models that describe the power consumption behavior of the network data transmission are therefore an essential tool in estimating the battery lifetime and in minimizing the energy usage of(More)
Searching for mobile data offloading solutions has been topical in recent years. In this paper, we present a collaborative WiFi-based mobile data offloading architecture - Metropolitan Advanced Delivery Network (MADNet), targeting at improving the energy efficiency for smartphones. According to our measurements,WiFi-based mobile data offloading for moving(More)
We propose a scalable Internet system for continuous collection of crowd-sourced video from devices such as Google Glass. Our hybrid cloud architecture, GigaSight, is effectively a Content Delivery Network (CDN) in reverse. It achieves scalability by decentralizing the collection infrastructure using cloudlets based on virtual machines~(VMs). Based on time,(More)
Mobile crowdsensing is becoming a vital technique for environment monitoring, infrastructure management, and social computing. However, deploying mobile crowdsensing applications in large-scale environments is not a trivial task. It creates a tremendous burden on application developers as well as mobile users. In this paper we try to reveal the barriers(More)
OBJECTIVE To evaluate the clinicopathological features of ovarian Sertoli-Leydig cell tumors (SLCTs) and to explore the reasonable therapy. METHODS A total of 40 cases of SLCTs were retrospectively reviewed. RESULTS The incidence of SLCTs was 0.41%, with a median age of 28 years. All tumors were confined to one ovary. Four tumors were well(More)